2. Neuronal Signaling Apoptosis Metabolic Enzyme/Protease
  3. α-synuclein Apoptosis Drug Metabolite
  4. Dopal

Dopal is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal can be used in research related to Parkinson's disease.

For research use only. We do not sell to patients.

Dopal

Dopal Chemical Structure

CAS No. : 5707-55-1

Size Price Stock Quantity
Solvent
5 mg (65.72 mM * 500 μL in Methanol) In-stock
Solvent
10 mg (65.72 mM * 1 mL in Methanol) In-stock

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Other Forms of Dopal:

Dopal Related Antibodies

Top Publications Citing Use of Products

View All α-synuclein Isoform Specific Products:

View All Isoforms
α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dopal is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal can be used in research related to Parkinson's disease[1][2].

IC50 & Target[1]

α-synuclein Aggregation

 

In Vitro

Dopal (1.5-1500 μM; 0-4 h) induces dose- and time-dependent aggregation of purified human recombinant α-synuclein in a cell-free system; aggregation initiates at concentrations as low as 1.5 μM, and large polymeric α-synuclein aggregates form at concentrations of 300 μM and above[1].
Dopal (3 μM-1 mM; 2-8 h) induces dose-dependent α-synuclein aggregation and cytotoxicity in SHSY-5Y cells overexpressing wild-type α-synuclein, with significant aggregation observed at concentrations ≥30 μM, oligomer formation initiated at 3 μM, and rapid cell death occurring at 1 mM[1].
Dopal (100-150 μM; 18-24 h) exhibits toxicity to SH-SY5Y cells and also induces cell apoptosis[2].
Dopal (100-200 μM; 16-24 h) induces the formation of α-synuclein-EGFP dimers in SH-SY5Y cells overexpressing α-synuclein-EGFP[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dopal Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Induced ~30% death in the SH-SY5Y cell population, significantly reducing cell viability compared to untreated controls.
In Vivo

Dopal (0.2-1.0 μg; stereotaxically injected into the substantia nigra; single dose) induces dose-dependent α-synuclein oligomer formation and causes loss of immunoreactivity for dopaminergic neuron markers in male Parkinson's disease rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 2-month-old, 300 g, unilateral stereotactic injection into substantia nigra)[1]
Dosage: 1.0 μg; 0.2 μg
Administration: stereotactic injection into substantia nigra; single dose
Result: Increased 50 to 170 kDa α-synuclein (AS) oligomers by 2.75-fold relative to vehicle control, with these oligomers accounting for 63% of total AS at 4 hours post-injection with 1.0 μg dose.
Induced a lesser increase in 50 to 170 kDa AS oligomers at 4 hours post-injection with 0.2 μg dose compared to 1.0 μg dose.
Caused loss of tyrosine hydroxylase immunoreactivity in the substantia nigra at 24 and 48 hours post-injection with both 1.0 μg and 0.2 μg doses. Failed to detect large AS aggregates via immunohistochemistry at 4, 24, or 48 hours post-injection.
Molecular Weight

152.15

Formula

C8H8O3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=CCC1=CC=C(O)C(O)=C1
Initial Source
Shipping

Shipping with dry ice.
Storage

-80°C
Purity & Documentation

Purity: 90.0%

SDS (393 KB)

COA (246 KB) HNMR (250 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Dopal Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dopal5707-55-1α-synucleinApoptosisDrug Metaboliteα-Syndopaminergic neuronSH-SY5Y cellsdopamineParkinson's diseaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Dopal
Cat. No.:
HY-121252
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.