5707-55-1
5707-55-1
Chemical Structure
Dopal
- CAS. Nr.: 5707-55-1
- Formula:C8H8O3
- Molecular Weight:152.15
IUPAC Name: 2-(3,4-dihydroxyphenyl)acetaldehyde
InChIKey: IADQVXRMSNIUEL-UHFFFAOYSA-N
SMILES: O=CCC1=CC=C(O)C(O)=C1
Biological Activity: Dopal is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal can be used in research related to Parkinson's disease[1][2].
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Dopal | Dopal is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal can be used in research related to Parkinson's disease. | |||||||||||||||||||||
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Dopal (purity>80%) | Dopal (purity>80%) is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal (purity>80%) exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal (purity>80%) can be used in research related to Parkinson's disease. | |||||||||||||||||||||
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Dopal-d5 | Dopal-d5 is the deuterium labeled Dopal (HY-121252). Dopal is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal can be used in research related to Parkinson's disease. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.88
HY-N18874-Allylcatechol -
Similarity Score 0.87
HY-N0295Protocatechualdehyde -
Similarity Score 0.84
HY-W2657574-Ethylcatechol -
Similarity Score 0.83
HY-N16732,5-Dihydroxybenzaldehyde -
Similarity Score 0.83
HY-W007539R2,4-Dihydroxybenzaldehyde (Standard) -
Similarity Score 0.83
HY-B0451Dopamine -
Similarity Score 0.83
HY-N0570Hydroxytyrosol -
Similarity Score 0.83
HY-W0010803,4-Dihydroxybenzeneacetic acid -
Similarity Score 0.83
HY-W168309Atrans-Caffeic aldehyde -
Explore the MedChemAI to find more analogs
References
- [1]. Burke WJ, et al. Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine. Acta Neuropathol. 2008;115(2):193-203. [Content Brief]
- [2]. Bloch DN, et al. Scavenging neurotoxic aldehydes using lysine carbon dots. Nanoscale Adv. 2023;5(5):1356-1367. Published 2023 Jan 19. [Content Brief]
