2. Antibody-drug Conjugate/ADC Related Neuronal Signaling GPCR/G Protein
  3. Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor
  4. DOTA-JR11

DOTA-JR11  (Synonyms: Satoreotide tetraxetan)

Cat. No.: HY-P5128 Purity: 99.14%
COA
SDS
Handling Instructions Technical Support

DOTA-JR11 is a somatostatin receptor 2 （SSTR2）antagonist. DOTA-JR11 can be labeled by 68Ga, used for paired imaging in neuroendocrine tumors (NETs) research. DOTA-JR11 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

DOTA-JR11

DOTA-JR11 화학구조

CAS No. : 1039726-31-2

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

DOTA-JR11 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE DOTA-JR11

View All Radionuclide-Drug Conjugates (RDCs) Isoform Specific Products:

View All Isoforms
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

View All Somatostatin Receptor Isoform Specific Products:

View All Isoforms
SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

DOTA-JR11 is a somatostatin receptor 2 （SSTR2）antagonist. DOTA-JR11 can be labeled by 68Ga, used for paired imaging in neuroendocrine tumors (NETs) research[1]. DOTA-JR11 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

IC50 & Target

RDC Peptide

 

In Vitro

[68Ga]Ga-DOTA-JR11 (30 ± 5 GBq/μmol, 5-120 min) shows stable uptake in HEK293-SSTR2 cells, suitable for SSTR2-targeted research[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-JR11 Related Antibodies
In Vivo

[68Ga]Ga-DOTA-JR11 (1.85 MBq, i.v., single dose) shows high tumor uptake in HEK293-SSTR2 tumor model mice, suitable for tumor imaging[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HEK293-SSTR2 tumor mice model[2]
Dosage: 1.85 MBq
Administration: Intravenous injection (i.v.), single dose, measured at 5, 30, 60, and 120 min
Result: Caused tumor uptake to peak at 60 minutes, significantly higher than uptake in other organs.
Clinical Trial
분자량

1689.27

화학식

C74H98ClN19O21S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

DOTA-[p-Cl-Phe-cyclo(D-Cys-Phe-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2]
선적

Room temperature in continental US; may vary elsewhere.
보관

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도
In Vitro: 

DMSO : 25 mg/mL (14.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5920 mL 2.9599 mL 5.9197 mL
5 mM 0.1184 mL 0.5920 mL 1.1839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5920 mL 2.9599 mL 5.9197 mL 14.7993 mL
5 mM 0.1184 mL 0.5920 mL 1.1839 mL 2.9599 mL
10 mM 0.0592 mL 0.2960 mL 0.5920 mL 1.4799 mL
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DOTA-JR11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-JR111039726-31-2Satoreotide tetraxetanRadionuclide-Drug Conjugates (RDCs)Somatostatin ReceptorSSTRsSSTR68Gapaired imagingneuroendocrine tumorsHEK293-SSTR2 cellsHEK293-SSTR2 tumor mice modelInhibitorinhibitorinhibit

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상품명:
DOTA-JR11
Cat. No.:
HY-P5128
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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