DOTATATE (Synonyms: Oxodotreotide)

Name: DOTATATE
Brand: MedChemExpress
SKU: HY-106244
Rating: 5.0 (3 reviews)

Art. -Nr.: HY-106244 Reinheit: 99.95%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT). DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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Kundenspezifische Peptidsynthese

CAS. Nr. : 177943-88-3

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

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Based on 3 publication(s) in Google Scholar

Other Forms of DOTATATE:

DOTATATE acetate In-stock

3 Publications Citing Use of MCE DOTATATE

Bio/Physico-chemical Assay

: DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625. [Abstract]; Total absorbed dose to cell nucleus for range of added activity concentrations of both ¹⁶¹Tb- and ¹⁷⁷Lu-labeled DOTATATE (0-1.25 MBq/mL).

: DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625. [Abstract]; Radiolabeled DOTATATE (1 MBq/mL) resulted in a higher absorbed dose than did radiolabeled DOTA-LM3, because of DOTATATE's higher Bmax and higher internalization.

: DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625. [Abstract]; The nuclear dose-response data of both [¹⁷⁷Lu]Lu- and [¹⁶¹Tb]Tb-DOTATATE (0-25 Gy) were best fitted with a linear model and could be fitted with a common, single curve.

: DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625. [Abstract]; The saturation binding assay represented total binding and nonspecific binding for different added activity concentrations of [¹⁶¹Tb]Tb-DOTATATE (0-60 nM) with a fixed molar activity of 100 MBq/nmol.

: DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625. [Abstract]; Clonogenic survival of CA20948 cells after treatment with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE (0-1.5 MBq/mL) as a function of added activity concentration (MBq/mL).

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Radionuclide-Drug Conjugates (RDCs) Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)^[1]^[2]^[3]^[4]. DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

IC₅₀ & Target

RDC Peptide

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	547 1 Compound: DOTA-TOCA	In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=3) In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=3)	[PMID: 15828816]
CHO-K1	IC₅₀	>10 3 Compound: DOTA-TOCA	In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 1 expressed in CHO-K1 cells; (n=3) In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 1 expressed in CHO-K1 cells; (n=3)	[PMID: 15828816]
CHO-K1	IC₅₀	> 10000 1 Compound: DOTA-TOCA	In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 1 expressed in CHO-K1 cells; (n=3) In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 1 expressed in CHO-K1 cells; (n=3)	[PMID: 15828816]
CHO-K1	IC₅₀	547 1 Compound: DOTA-TOCA	In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=3) In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=3)	[PMID: 15828816]

In Vivo

¹⁷⁷Lu-DOTATATE shows excellent antitumor effects in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

1435.62

Formel

C₆₅H₉₀N₁₄O₁₉S₂

CAS. Nr.

177943-88-3

Appearance

Solid

Color

White to off-white

Sequence

{DOTA}-{d-Phe}-Cys-Tyr-{d-Trp}-Lys-Thr-Cys-Thr (Disulfide bridge:Cys2-Cys7)

Sequence Shortening

{DOTA}-{d-Phe}-CY-{d-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (69.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6966 mL	3.4828 mL	6.9656 mL
5 mM	0.1393 mL	0.6966 mL	1.3931 mL
10 mM	0.0697 mL	0.3483 mL	0.6966 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.95%

Select Batch:

Data Sheet (284 KB) SDS (393 KB)

COA (263 KB) LCMS (97 KB) Elemental Analysis Report (121 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S. [Content Brief]

[2]. Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10. [Content Brief]

[3]. Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):917-20. [Content Brief]

[4]. Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27(3):273-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.6966 mL	3.4828 mL	6.9656 mL	17.4141 mL
	5 mM	0.1393 mL	0.6966 mL	1.3931 mL	3.4828 mL
	10 mM	0.0697 mL	0.3483 mL	0.6966 mL	1.7414 mL
	15 mM	0.0464 mL	0.2322 mL	0.4644 mL	1.1609 mL
	20 mM	0.0348 mL	0.1741 mL	0.3483 mL	0.8707 mL
	25 mM	0.0279 mL	0.1393 mL	0.2786 mL	0.6966 mL
	30 mM	0.0232 mL	0.1161 mL	0.2322 mL	0.5805 mL
	40 mM	0.0174 mL	0.0871 mL	0.1741 mL	0.4354 mL
	50 mM	0.0139 mL	0.0697 mL	0.1393 mL	0.3483 mL
	60 mM	0.0116 mL	0.0580 mL	0.1161 mL	0.2902 mL

DOTATATE Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTATATE177943-88-3OxodotreotideRadionuclide-Drug Conjugates (RDCs)radionuclidespositronemissiontomographyPETimagingpeptidereceptorradionuclidetherapyPRRTtumorInhibitorinhibitorinhibit

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DOTATATE (Synonyms: Oxodotreotide)

Kundenbewertung

Other Forms of DOTATATE:

DOTATATE Related Antibodies

3 Publications Citing Use of MCE DOTATATE

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Radionuclide-Drug Conjugates (RDCs) Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

DOTATATE Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

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SAFETY DATA SHEET (SDS)

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