2. Apoptosis Metabolic Enzyme/Protease
  3. Ferroptosis Apoptosis Glutathione Peroxidase
  4. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW

DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW is a polypeptide targeting tenascin-X (Tenascin-X) that can be conjugated with liposomes and exosomes. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW specifically binds to Tenascin-X on the surface of cardiomyocytes, mediates receptor-dependent uptake of nanocarriers, enhances targeted drug delivery of cargo to cardiomyocytes, and increases drug accumulation in cardiac tissue. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW protects cardiomyocytes treated with LPS, alleviates oxidative stress, repairs mitochondrial function, inhibits ferroptosis and apoptosis, and downregulates the secretion of pro-inflammatory cytokines at the same time. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW improves cardiac injury and pathological morphology in mice with sepsis-induced cardiomyopathy, restores GPX4 expression, and promotes the internalization of cardiomyocyte-derived exosomes, making it suitable for related research on sepsis-induced cardiomyopathy, myocardial ischemia-reperfusion injury, and other conditions.

For research use only. We do not sell to patients.

DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW

DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW Chemical Structure

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Other Forms of DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW:

DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW Related Antibodies

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Description

DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW is a polypeptide targeting tenascin-X (Tenascin-X) that can be conjugated with liposomes and exosomes. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW specifically binds to Tenascin-X on the surface of cardiomyocytes, mediates receptor-dependent uptake of nanocarriers, enhances targeted drug delivery of cargo to cardiomyocytes, and increases drug accumulation in cardiac tissue. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW protects cardiomyocytes treated with LPS, alleviates oxidative stress, repairs mitochondrial function, inhibits ferroptosis and apoptosis, and downregulates the secretion of pro-inflammatory cytokines at the same time. DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW improves cardiac injury and pathological morphology in mice with sepsis-induced cardiomyopathy, restores GPX4 expression, and promotes the internalization of cardiomyocyte-derived exosomes, making it suitable for related research on sepsis-induced cardiomyopathy, myocardial ischemia-reperfusion injury, and other conditions[1][2].

IC50 & Target

GPX4

 

In Vitro

DSPE-PEG-CMP-EXO (20 μM miR302 mimic; 30 min loading incubation, 0-72 h stability testing, 1-48 h release quantification) efficiently encapsulates 20 μM miR302 mimic, protects miR302 for 24 h in serum-containing medium, and achieves 90% cumulative release of miR302 within 48 h[2].
DSPE-PEG-CMP-miR302-EXO (6 h hypoxia, 16 h reperfusion) significantly upregulates miR302 expression, increases Ki67 and Yap protein levels, and enhances proliferation of H9C2 cardiomyocytes exposed to in vitro ischemia/reperfusion injury[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW Related Antibodies
In Vivo

DSPE-PEG-CMP (0.25 μg per mouse; i.v.; every 2 days; 4 weeks) alone does not significantly attenuate myocardial I/R injury, reduce apoptosis and inflammation, or improve cardiac function in male C57BL/6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 8-10 weeks old, 20-25 g, left anterior descending coronary artery ligated for 60 minutes followed by reperfusion)[2]
Dosage: 0.25 μg (DSPE-PEG-CMP) per mouse
Administration: i.v.; every 2 days; 4 weeks
Result: Showed minimal to no significant improvement in serum levels of cardiac injury markers (cTnI, CKMB) and proinflammatory factors (TNF-α, IL-1β) compared to the model group.
Showed no significant reduction in cardiomyocyte necrosis, structural disorder, or myocardial apoptosis rate compared to the model group.
Showed no significant improvement in left ventricular ejection fraction (EF), fractional shortening (FS), LV Mass Index, LVAWd, LVAWs, LV VOLd, LV VOLs, LVIDd, LVIDs, LVPWd, or LVPWs compared to the model group.
Molecular Weight

4088 (Average)

Appearance

Solid

Color

White to off-white

SMILES

[O-]P(OCCNC(OCCOCC(N[C@@H](CC1=CNC2=CC=CC=C21)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N3CCC[C@H]3C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@](C(NCC(N[C@H](C(N[C@@H](C(O)=O)CC4=CNC5=CC=CC=C54)=O)CO)=O)=O)([H])[C@H](O)C)=O)=O)CCC/N=C(N)\N)=O)CC(C)C)=O)C)=O)CCCNC(N)=N)=O)C(C)C)=O)([H])[C@@H](C)O)=O)C(C)C)=O)C(C)C)=O)=O)=O)C)=O)CCC(O)=O)=O)CO)=O)CC(C)C)=O)=O)=O)(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)(OC(CCCCCCCCCCCCCCCCC)=O)[H])=O.[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DSPE-PEG2000-WLSEAGPVVTVRALRGTGSWFerroptosisApoptosisGlutathione PeroxidaseH9c2 cellscardiac tissueferroptosissepsis-induced cardiomyopathyoxidative stressapoptosisC57BL/6 micemitochondrial membrane potentialcardiomyocytestenascin-XInhibitorinhibitorinhibit

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DSPE-PEG2000-WLSEAGPVVTVRALRGTGSW
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