2. GPCR/G Protein
  3. GCGR
  4. Ecnoglutide

Ecnoglutide (XW003) is a long-acting, cAMP-biased glucagon-like peptide 1 (GLP-1) receptor agonist. Ecnoglutide can be used for research of T2DM and obesity.

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Ecnoglutide

Ecnoglutide Estructura química

No. CAS : 2459531-73-6

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Ecnoglutide Related Antibodies

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Descripciòn

Ecnoglutide (XW003) is a long-acting, cAMP-biased glucagon-like peptide 1 (GLP-1) receptor agonist. Ecnoglutide can be used for research of T2DM and obesity[1][2].

In Vitro

Ecnoglutide induces cAMP but not GLP-1 receptor internalization (EC50 = 0.018 nM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ecnoglutide Related Antibodies
In Vivo

Ecnoglutide (0.015, 0.15 mg/kg, s.c., a single time) reduces blood glucose, promotes insulin induction, and leads to more pronounced body weight reduction compared to Semaglutide (HY-114118) in db/db mice[2].
Ecnoglutide (1 mg/kg, s.c., rats) shows the T1/2 (h), Tmax (h), Cmax (nM), AUClast (h*nM), MRT (h) values of 11.7, 18 .0, 387.3, 16274.8, 25.4 respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
Peso molecular

4284.76

Fòrmula

C194H304N48O61
No. CAS
Appearance

Solid

Color

White to off-white

Sequence

His-Val-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Arg-Glu-Phe-Ile-Lys-(AEEA-AEEA-{γ-Glu}-C18 diacid)-Trp-Leu-Val-Arg-Gly-Arg-Gly
Sequence Shortening

HVEGTFTSDVSSYLEEQAAREFIK-(AEEA-AEEA-{γ-Glu}-C18 diacid)-WLVRGRG
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvente y solubilidad
In Vitro: 

H2O : 20 mg/mL (4.67 mM; ultrasonic and adjust pH to 12 with 1M NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2334 mL 1.1669 mL 2.3339 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Referencias

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2334 mL 1.1669 mL 2.3339 mL 5.8346 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ecnoglutide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ecnoglutide2459531-73-6XW003XW 003XW-003GCGRGlucagon ReceptorcAMPT2DMobesityInhibitorinhibitorinhibit

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Nombre del producto:
Ecnoglutide
Cat. No.:
HY-P3366
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