2. JAK/STAT Signaling Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. EGFR Dihydrofolate reductase (DHFR)
  4. EGFR/HER2/DHFR-IN-2

EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR (IC50: 0.248, 0.156, 0.138 μM respectively). EGFR/HER2/DHFR-IN-2 has anticancer activities against a panel of cancer cells (IC50: 9.14, 7.33, 14.18, 24.87, 20.07, 6.16 μM for Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7 cells). EGFR/HER2/DHFR-IN-2 reduce breast cancer tumor growth.

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EGFR/HER2/DHFR-IN-2

EGFR/HER2/DHFR-IN-2 Chemische Struktur

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EGFR/HER2/DHFR-IN-2 Related Antibodies

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Beschreibung

EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR (IC50: 0.248, 0.156, 0.138 μM respectively). EGFR/HER2/DHFR-IN-2 has anticancer activities against a panel of cancer cells (IC50: 9.14, 7.33, 14.18, 24.87, 20.07, 6.16 μM for Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7 cells). EGFR/HER2/DHFR-IN-2 reduce breast cancer tumor growth[1].

IC50 & Target

0.248, 0.156, 0.138 μM (EGFR, HER2, DHFR)[1].
Molekulargewicht

407.30

Formel

C22H19BrN2O
SMILES

N#CC1=C(OCCC)N=C(C2=CC=C(C)C=C2)C=C1C3=CC=C(Br)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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EGFR/HER2/DHFR-IN-2 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2/DHFR-IN-2EGFRDihydrofolate reductase (DHFR)Epidermal growth factor receptorErbB-1HER1Hep G2HeLaHEp-2HCT 116PC-3MCF7breast cancertumorInhibitorinhibitorinhibit

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