2. Immunology/Inflammation
  3. LAG-3
  4. Favezelimab

Favezelimab  (Synonyms: MK-4280; Mavezelimab)

Cat. No.: HY-P99613 Pureza: 97.79%
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Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand, MHC class II molecules. Favezelimab is applicable to research on relapsed/refractory classical Hodgkin lymphoma, relapsed/refractory diffuse large B-cell lymphoma, and relapsed/refractory indolent B-cell lymphoma. For the isotype control of Favezelimab, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

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No. CAS : 2231068-83-8

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This product is a controlled substance and not for sale in your territory.

Favezelimab Related Antibodies

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Descripciòn

Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand, MHC class II molecules. Favezelimab is applicable to research on relapsed/refractory classical Hodgkin lymphoma, relapsed/refractory diffuse large B-cell lymphoma, and relapsed/refractory indolent B-cell lymphoma[1]. For the isotype control of Favezelimab, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

LAG3/CD223
In Vitro

Lymphocyte activation gene-3 (LAG-3) is a cell surface immunomodulatory receptor commonly coexpressed with PD-1 on exhausted T cells and may serve as an escape pathway for lymphoma subjected to PD-1 blockade. Dual blockade of PD-1 and LAG-3 showed synergistic activity in mouse models of colon adenocarcinoma and fibrosarcoma.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Favezelimab Related Antibodies
Ensayo clínico
Gene ID

3902  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

145.98 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Favezelimab]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Flow cytometric analysis of 1X106 Jurkat cells with Favezelimab (HY-P99613, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
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Referencias
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Favezelimab Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Favezelimab2231068-83-8MK-4280 MavezelimabMK4280MK 4280LAG-3Lymphocyte activation gene-3CD223relapsed/refractory classic hodgkin lymphomarelapsed/refractory indolent b-cell lymphomasrelapsed/refractory diffuse large b-cell lymphomaMHC class IIInhibitorinhibitorinhibit

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Nombre del producto:
Favezelimab
Cat. No.:
HY-P99613
Cantidad:
MCE Japan Authorized Agent:

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