フルオキセチン塩酸塩 (Synonyms: Fluoxetine (hydrochloride); LY 110140)

Name: Fluoxetine hydrochloride
Brand: MedChemExpress
SKU: HY-B0102A
Rating: 5.0 (40 reviews)

製品番号: HY-B0102A 純度: 99.97%: Data Sheet SDS COA 取扱説明書
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Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor.

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CAS 番号 : 56296-78-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$25	在庫あり	Estimated Time of Arrival: December 31
10 mg	$35	在庫あり	Estimated Time of Arrival: December 31
25 mg	$55	在庫あり	Estimated Time of Arrival: December 31
50 mg	$70	在庫あり	Estimated Time of Arrival: December 31
100 mg	$90	在庫あり	Estimated Time of Arrival: December 31
500 mg	$250	在庫あり	Estimated Time of Arrival: December 31
1 g		お問い合わせ
5 g		お問い合わせ

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カスタマーレビュー

Based on 40 publication(s) in Google Scholar

Other Forms of Fluoxetine hydrochloride:

(S)-Fluoxetine hydrochloride 在庫あり
(R)-Fluoxetine hydrochloride 在庫あり
Fluoxetine 在庫あり
Fluoxetine hydrochloride (Standard) 在庫あり

顧客検証

In Vivo Imaging

IHC

In Vivo Efficacy Study

: Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]; Ovarian cancer ID8 syngeneic model testing fluoxetine effect, Fluoxetine treatment (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest), Cisplatin (5 mg/kg, twice/week, intraperitoneal injection in indicated time windows). The figure shows representative bioluminescence imaging results.

: Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Dec 17:S1550-4131(25)00495-4. [Abstract]; Fluoxetine (20 mg/kg over drinking water starting 7 days before first chemotherapy and continued until harvest). Ovarian cancer PDX #1795 mouse model treated with PARPi (Olaparib) alone or with a combination of Fluoxetine.

: Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]; Fluoxetine (20 mg/kg; ip). Representative images of DCX positive cells in the DG of hippocampus in different group.

: Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Brain Behav Immun. 2021 Jul:95:142-153. [Abstract]; Fluoxetine (20 mg/kg; ip). Representative immunoblots of DCX and NeuN expression levels in different groups.

: Fluoxetine hydrochloride purchased from MedChemExpress. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267. [Abstract]; Representative images showing the restoration effect of harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg; ip) was used as a positive control, and all data were shown as mean ± SEM.

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製品説明

Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor.

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	150 1 Compound: fluoxetine, prozac	Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
HEK293	IC₅₀	150 1 Compound: fluoxetine, prozac	Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
HEK293	IC₅₀	18400 1 Compound: fluoxetine, prozac	Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
Spermatozoa	ED₅₀	0.00007 74 Compound: Fluoxetine.HCl	Spermicidal activity against human spermatozoa Spermicidal activity against human spermatozoa	[PMID: 16464584]
HEK293	IC₅₀	150 1 Compound: fluoxetine, prozac	Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
HEK293	IC₅₀	4410 1 Compound: fluoxetine, prozac	Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
HEK293	IC₅₀	4410 1 Compound: fluoxetine, prozac	Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
HEK293	IC₅₀	18400 1 Compound: fluoxetine, prozac	Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
HEK293	IC₅₀	4410 1 Compound: fluoxetine, prozac	Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
HEK293	IC₅₀	18400 1 Compound: fluoxetine, prozac	Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay	[PMID: 22938049]
Spermatozoa	ED₅₀	0.00007 74 Compound: Fluoxetine.HCl	Spermicidal activity against human spermatozoa Spermicidal activity against human spermatozoa	[PMID: 16464584]

体外実験

Fluoxetine hydrochloride (LY 110140) blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell^[1]. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex^[2]. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus^[3]. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Fluoxetine hydrochloride (LY 110140) treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats^[1]. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells compared with the control group^[2]. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

345.79

分子式

C₁₇H₁₉ClF₃NO

CAS 番号

56296-78-7

Appearance

Solid

Color

White to off-white

SMILES

FC(C1=CC=C(OC(C2=CC=CC=C2)CCNC)C=C1)(F)F.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : ≥ 25 mg/mL (72.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 8.33 mg/mL (24.09 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8919 mL	14.4596 mL	28.9193 mL
5 mM	0.5784 mL	2.8919 mL	5.7839 mL
10 mM	0.2892 mL	1.4460 mL	2.8919 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 2 mg/mL (5.78 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Protocol 2

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 25 mg/mL (72.30 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.97%

Select Batch:

データシート (279 KB) SDS (620 KB)

COA (247 KB) HNMR (156 KB) LCMS (84 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71 [Content Brief]

[2]. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. [Content Brief]

[3]. Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. [Content Brief]

[4]. Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61 [Content Brief]

[5]. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. [Content Brief]

[6]. Su WJ, et al. Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance. J Neuroinflammation. 2017 Oct 30;14(1):210. [Content Brief]

動物実験
^[2]

Male Sprague-Dawley rats weighing 250-300 g are housed under a 12-hour light/12-hour dark cycle (lights on at 7:00 am, lights off at 7:00 pm) and at constant temperature (25°C) and humidity and allowed free access to food and water. For chronic drug treatments, rats are administered fluoxetine (5 mg/kg/day) or saline by intraperitoneal (IP) injection once daily and olanzapine or vehicle in the drinking water for 21 days (vehicle-treated control, fluoxetine, and olanzapine alone) plus the combination of fluoxetine and olanzapine. For combination treatment, olanzapine is chosen because fluoxetine is known to interfere with the metabolism of olanzapine and raise the blood levels by up to 4-6 times. Olanzapine is dissolved in hydrochloric acid (HCl), then adjusted back to pH 6 with 1 N sodium hydroxide to make the stock solution of 3 mg/mL concentration. The same amount of vehicle solution is added to the water for the control animals. Fluid intake is measured three times per week, and drinking bottles are replenwashed with fresh drug solution. There are no differences in fluid intake among the treatment groups. For subchronic treatment, drugs are administered exactly the same way but for a total period of 7 days.

MedChemExpress (MCE) はこれらの方法の精度を確認していません。こちらは参照専用です。

参考文献

[1]. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71 [Content Brief]

[2]. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. [Content Brief]

[3]. Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. [Content Brief]

[4]. Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61 [Content Brief]

[5]. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. [Content Brief]

[6]. Su WJ, et al. Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance. J Neuroinflammation. 2017 Oct 30;14(1):210. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.8919 mL	14.4596 mL	28.9193 mL	72.2982 mL
	5 mM	0.5784 mL	2.8919 mL	5.7839 mL	14.4596 mL
	10 mM	0.2892 mL	1.4460 mL	2.8919 mL	7.2298 mL
	15 mM	0.1928 mL	0.9640 mL	1.9280 mL	4.8199 mL
	20 mM	0.1446 mL	0.7230 mL	1.4460 mL	3.6149 mL
DMSO	25 mM	0.1157 mL	0.5784 mL	1.1568 mL	2.8919 mL
	30 mM	0.0964 mL	0.4820 mL	0.9640 mL	2.4099 mL
	40 mM	0.0723 mL	0.3615 mL	0.7230 mL	1.8075 mL
	50 mM	0.0578 mL	0.2892 mL	0.5784 mL	1.4460 mL
	60 mM	0.0482 mL	0.2410 mL	0.4820 mL	1.2050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Fluoxetine hydrochloride Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluoxetine56296-78-7LY 110140LY110140LY-110140Serotonin TransporterAutophagy5-HTTSERTSLC6A4Inhibitorinhibitorinhibit

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フルオキセチン塩酸塩 (Synonyms: Fluoxetine (hydrochloride); LY 110140)

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Other Forms of Fluoxetine hydrochloride:

フルオキセチン塩酸塩 関連抗体

顧客検証

おすすめ

•関連小分子:

•関連タンパク質:

生物活性

プロトコル

純度とドキュメンテーション

参考文献

カスタマーレビュー

フルオキセチン塩酸塩 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Fluoxetine hydrochloride Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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フルオキセチン塩酸塩関連抗体

フルオキセチン塩酸塩関連抗体