2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Fulzerasib

Fulzerasib  (Synonyms: IBI351; GFH925)

Cat. No.: HY-152848 Purity: 99.60%
COA
SDS
Handling Instructions Technical Support

Fulzerasib (GFH925) is an irreversible KRAS G12C inhibitor, has a synergistic anti-cancer effect with cetuximab (HY-P9905)..

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Fulzerasib

Fulzerasib 화학구조

CAS No. : 2641747-54-6

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

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Fulzerasib Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Fulzerasib (GFH925) is an irreversible KRAS G12C inhibitor, has a synergistic anti-cancer effect with cetuximab (HY-P9905).[1][2].

IC50 & Target

KRAS(G12C)

 

In Vitro

Fulzerasib covalently inhibits GDP/GTP nucleotide exchange on KRAS G12C (IC50: 29 nM), locking KRAS in its inactive GDP-bound state (RAS-GTP IC50: 74 nM), thereby blocking the KRAS signaling pathway (pERK IC50: 37 nM)[1].
Fulzerasib inhibits the growth of tumor cell lines carrying the KRAS G12C mutation (IC50: 2-20 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fulzerasib Related Antibodies
In Vivo

Fulzerasib shows strong anti-tumor activity in various models, including the pancreatic cancer cell line MIA Paca-2 CDX, human lung adenocarcinoma NCI-H358 CDX, patient-derived xenograft colon adenocarcinoma SW837 CDX, and lung cancer LU2529 PDX[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
분자량

617.07

화학식

C32H30ClFN6O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=C)N1CCN2C(C3=C(N4C5=C(C(C)C)N=CC=C5C)N=C(C6=C(O)C=CC=C6F)C(Cl)=C3)=C(N(C)C([C@@]2([H])C1)=O)C4=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 116.67 mg/mL (189.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6206 mL 8.1028 mL 16.2056 mL
5 mM 0.3241 mL 1.6206 mL 3.2411 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6206 mL 8.1028 mL 16.2056 mL 40.5140 mL
5 mM 0.3241 mL 1.6206 mL 3.2411 mL 8.1028 mL
10 mM 0.1621 mL 0.8103 mL 1.6206 mL 4.0514 mL
15 mM 0.1080 mL 0.5402 mL 1.0804 mL 2.7009 mL
20 mM 0.0810 mL 0.4051 mL 0.8103 mL 2.0257 mL
25 mM 0.0648 mL 0.3241 mL 0.6482 mL 1.6206 mL
30 mM 0.0540 mL 0.2701 mL 0.5402 mL 1.3505 mL
40 mM 0.0405 mL 0.2026 mL 0.4051 mL 1.0129 mL
50 mM 0.0324 mL 0.1621 mL 0.3241 mL 0.8103 mL
60 mM 0.0270 mL 0.1350 mL 0.2701 mL 0.6752 mL
80 mM 0.0203 mL 0.1013 mL 0.2026 mL 0.5064 mL
100 mM 0.0162 mL 0.0810 mL 0.1621 mL 0.4051 mL
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Fulzerasib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fulzerasib2641747-54-6IBI351 GFH925IBI 351IBI-351GFH925GFH 925GFH-925RasKRAS G12CNSCLCInhibitorinhibitorinhibit

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상품명:
Fulzerasib
Cat. No.:
HY-152848
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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