2. Apoptosis
  3. Apoptosis
  4. Fusicoccin

Fusicoccin  (Synonyms: Fusicoccin A)

製品番号: HY-122815 純度: 91.00%
COA 取扱説明書 Technical Support

Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H+-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity.

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Fusicoccin

Fusicoccin 構造式

CAS 番号 : 20108-30-9

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Fusicoccin 関連抗体

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製品説明

Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H+-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity[1][2][3][4].

体外実験

Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC50=29 mM)[3].
Fusicoccin A activates the plasma membrane H+-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC50 growth inhibitory concentration of fusicoccin A is 92 μM in the U373-MG cells and 83 μM in the Hs683 glioma cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fusicoccin 関連抗体
分子量

680.82

分子式

C36H56O12
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

C[C@](/C=C([C@H]1COC)\[C@](CC1)([H])[C@H]2C)([C@H]3O)C([C@H]([C@@H]2O)O[C@@H](O[C@@H]4COC(C)(C)C=C)[C@@H]([C@H]([C@@H]4O)OC(C)=O)O)=C(C3)[C@H](C)COC(C)=O
Structure Classification
Initial Source

Fusicoccum amygdali
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション

純度: 96.30%

COA (263 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献
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Fusicoccin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fusicoccin20108-30-9Fusicoccin AApoptosisATPasestabilizerprotein-proteininteractionsGBMcellscancerInhibitorinhibitorinhibit

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Fusicoccin
製品番号:
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