2. Immunology/Inflammation
  3. Mucin
  4. Gatipotuzumab

Gatipotuzumab  (Synonyms: PankoMab; DS-3939a antibody)

Art. -Nr.: HY-P99634 Reinheit: 99.204%
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Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC).

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CAS. Nr. : 1264737-26-9

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Gatipotuzumab Related Antibodies

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Beschreibung

Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC)[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

MUC1
In Vitro

Gatipotuzumab (PankoMab) strongly binds to a short MUC1 peptide of 30 amino acids comprising 1.5 TRs when it is glycosylated with GalNAcα at the T of the PDTRP-sequence, but not if the same peptide is not glycosylated[2].
Gatipotuzumab (PankoMab) (1 h) has a high-affinity towards tumour cells (KD of 0.91, 3.03, 3.84 and 7.14 nM towards NM-D4, ZR75-1, MCF-7 and T-47D, respectively)[2].
Gatipotuzumab (PankoMab) (0-5 μg/mL; 4 h) shows specific anti-tumor antibody-dependent cell cytotoxicity activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gatipotuzumab Related Antibodies
Klinische Studie
Gene ID

4582  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

146.56 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Gatipotuzumab]
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Mucin-1/MUC1 Protein, Human (269a.a, HEK293, His, HY-P78733) can bind Gatipotuzumab. The EC50 for this effect is 26.65 ng/mL.
  • Flow Cytometry analysis of Hela cells labelling MUC1 (red) with Gatipotuzumabt (anti-MUC1) (HY-P99634). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Reinheit & Dokumentation

Purity: 99.204%

SDS (251 KB)

COA (232 KB) SDS-PAGE (101 KB) SEC-HPLC (243 KB)

Inhibitory Antibodies User Guide (603 KB)
Verweise
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Gatipotuzumab Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gatipotuzumab1264737-26-9PankoMab DS-3939a antibodyMucinADCCmucin-1MUC1tumor-specificantibody-dependent cell cytotoxicityInhibitorinhibitorinhibit

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