1264737-26-9
1264737-26-9
Chemical Structure
Gatipotuzumab
Synonym(s): PankoMab; DS-3939a antibody
- CAS No.: 1264737-26-9
- Formula:N/A
- Molecular Weight:(146.56 kDa)
IUPAC Name: 8-methyl-5-oxa-2,8-diazaspiro[3.5]nonane
SMILES: [Gatipotuzumab]
Biological Activity: Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC)[1][2].
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Gatipotuzumab | 99.204% | Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC). | ||||||||||||||||||||
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References
- [1]. Macchini M, et al. Results from the primary analysis of a 30 patient extension of the GATTO study, a phase Ib study combining the anti-MUC1 gatipotuzumab (GAT) with the anti-EGFR tomuzotuximab (TO) or panitumumab in patients with refractory solid tumors. European Journal of Cancer, 2020, 138: S5-S6.
- [2]. Danielczyk A, et al. PankoMab: a potent new generation anti-tumour MUC1 antibody. Cancer Immunol Immunother. 2006 Nov;55(11):1337-47. [Content Brief]
Keywords
