Gefitinib impurity 1

Cat. No.: HY-131257 Purity: 99.59%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Gefitinib impurity 1 화학구조

CAS No. : 675126-26-8

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Gefitinib impurity 1:

Gefitinib impurity 1 (Standard) 견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

분자량

321.33

화학식

C₁₅H₁₉N₃O₅

CAS No.

675126-26-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 50 mg/mL (155.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1121 mL	15.5603 mL	31.1207 mL
5 mM	0.6224 mL	3.1121 mL	6.2241 mL
10 mM	0.3112 mL	1.5560 mL	3.1121 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.59%

Select Batch:

Data Sheet (268 KB) SDS (394 KB)

COA (247 KB) HNMR (252 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1121 mL	15.5603 mL	31.1207 mL	77.8016 mL
	5 mM	0.6224 mL	3.1121 mL	6.2241 mL	15.5603 mL
	10 mM	0.3112 mL	1.5560 mL	3.1121 mL	7.7802 mL
	15 mM	0.2075 mL	1.0374 mL	2.0747 mL	5.1868 mL
	20 mM	0.1556 mL	0.7780 mL	1.5560 mL	3.8901 mL
	25 mM	0.1245 mL	0.6224 mL	1.2448 mL	3.1121 mL
	30 mM	0.1037 mL	0.5187 mL	1.0374 mL	2.5934 mL
	40 mM	0.0778 mL	0.3890 mL	0.7780 mL	1.9450 mL
	50 mM	0.0622 mL	0.3112 mL	0.6224 mL	1.5560 mL
	60 mM	0.0519 mL	0.2593 mL	0.5187 mL	1.2967 mL
	80 mM	0.0389 mL	0.1945 mL	0.3890 mL	0.9725 mL
	100 mM	0.0311 mL	0.1556 mL	0.3112 mL	0.7780 mL