675126-26-8
Chemical Structure
Gefitinib impurity 1
- CAS No.: 675126-26-8
- Formula:C15H19N3O5
- Molecular Weight:321.33
IUPAC Name: 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
InChIKey: FYCDMKYKGPHRFW-UHFFFAOYSA-N
SMILES: N#CC1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O
Biological Activity: Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
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Gefitinib impurity 1 | 99.59% | Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity. | ||||||||||||||||||||
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Gefitinib impurity 1 (Standard) | ≥98% | Hydroxymetronidazole (Standard) is the analytical standard of Hydroxymetronidazole. This product is intended for research and analytical applications. Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle. | ||||||||||||||||||||
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