2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. [Glp5,(Me)Phe8,Sar9] Substance P (5-11)

[Glp5,(Me)Phe8,Sar9] Substance P (5-11)  (Synonyms: DiMe-C7)

製品番号: HY-P3801 純度: 99.61%
COA 取扱説明書 Technical Support

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

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[Glp5,(Me)Phe8,Sar9] Substance P (5-11)

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 構造式

CAS 番号 : 77128-69-9

容量 価格（税別） 在庫状況 数量
1 mg $30 在庫あり
5 mg $65 在庫あり
10 mg $110 在庫あり
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100 mg   お問い合わせ  

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[Glp5,(Me)Phe8,Sar9] Substance P (5-11) 関連抗体

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製品説明

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats[1][2][3].

体内実験

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 μg/side; inject into the ventral tegmental area; single) exhibits selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain[1].
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 μg/side; inject into the ventral tegmental area; single) increases motor activity and induces recovery of addictive agent-seeking behavior in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (300-350 g)[1].
Dosage: 2 µg/side
Administration: Inject into the ventral tegmental area; single
Result: Selectively activated mesolimbic and mesocortical dopamine metabolism.
Animal Model: Male Wistar rats (300-350 g)[2].
Dosage: 0.5, 1.5, 3 µg/side
Administration: Inject into the ventral tegmental area; single
Result: Significantly increased locomotor activity when at 3 µg/side.
分子量

880.06

分子式

C43H61N9O9S
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2
Sequence Shortening

pGlp-QF(-Me)F-Sar-LM-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (113.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1363 mL 5.6814 mL 11.3629 mL
5 mM 0.2273 mL 1.1363 mL 2.2726 mL
10 mM 0.1136 mL 0.5681 mL 1.1363 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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純度とドキュメンテーション

純度: 99.61%

COA (249 KB) LCMS (94 KB) Elemental Analysis Report (109 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1363 mL 5.6814 mL 11.3629 mL 28.4072 mL
5 mM 0.2273 mL 1.1363 mL 2.2726 mL 5.6814 mL
10 mM 0.1136 mL 0.5681 mL 1.1363 mL 2.8407 mL
15 mM 0.0758 mL 0.3788 mL 0.7575 mL 1.8938 mL
20 mM 0.0568 mL 0.2841 mL 0.5681 mL 1.4204 mL
25 mM 0.0455 mL 0.2273 mL 0.4545 mL 1.1363 mL
30 mM 0.0379 mL 0.1894 mL 0.3788 mL 0.9469 mL
40 mM 0.0284 mL 0.1420 mL 0.2841 mL 0.7102 mL
50 mM 0.0227 mL 0.1136 mL 0.2273 mL 0.5681 mL
60 mM 0.0189 mL 0.0947 mL 0.1894 mL 0.4735 mL
80 mM 0.0142 mL 0.0710 mL 0.1420 mL 0.3551 mL
100 mM 0.0114 mL 0.0568 mL 0.1136 mL 0.2841 mL
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[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Glp5,(Me)Phe8,Sar9] Substance P (5-11)77128-69-9DiMe-C7Neurokinin ReceptorNK receptorTachykinin receptorseeking behaviordopamineneuropeptideNK1RInhibitorinhibitorinhibit

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製品名:
[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
製品番号:
HY-P3801
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