HDMAPP triammonium

Name: HDMAPP triammonium
Brand: MedChemExpress
SKU: HY-145498
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製品番号: HY-145498 純度: 90.0%: Data Sheet SDS COA 取扱説明書
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HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC₅₀=0.39 nM, TNF-α).

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HDMAPP triammonium 構造式

CAS 番号 : 443892-56-6

容量	価格（税別）	在庫状況	数量
500 μg	$178	在庫あり	Estimated Time of Arrival: December 31

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

TNF Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

TNFRSF1A

体外実験

HDMAPP triammonium (compound 3E) (2 μM) increases TNF-α release levels in primary polyclonal human Vγ9Vδ2 T cells and has stimulatory bioactivity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

HDMAPP triammonium (compound 3E) (0.02-2.5 mg/kg; iv; 15 days) significantly increases γδ cells in a cynomolgus monkey model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Nonhuman Primate Model in Cynomolgus^[1]
Dosage:	0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg
Administration:	Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
Result:	Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 2.5 mg/kg.

分子量

313.18

分子式

C₅H₂₁N₃O₈P₂

CAS 番号

443892-56-6

Appearance

Solid

Color

White to off-white

SMILES

OC/C(C)=C/COP(OP(O)(O)=O)(O)=O.N.N.N

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

PBS : 10 mg/mL (31.93 mM; ultrasonic and warming and adjust pH to 7.2)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1931 mL	15.9653 mL	31.9305 mL
5 mM	0.6386 mL	3.1931 mL	6.3861 mL
10 mM	0.3193 mL	1.5965 mL	3.1931 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

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体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 90.0%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (245 KB) HNMR (509 KB) MS (234 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51(6):1747-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

PBS	1 mM	3.1931 mL	15.9653 mL	31.9305 mL	79.8263 mL
	5 mM	0.6386 mL	3.1931 mL	6.3861 mL	15.9653 mL
	10 mM	0.3193 mL	1.5965 mL	3.1931 mL	7.9826 mL
	15 mM	0.2129 mL	1.0644 mL	2.1287 mL	5.3218 mL
	20 mM	0.1597 mL	0.7983 mL	1.5965 mL	3.9913 mL
	25 mM	0.1277 mL	0.6386 mL	1.2772 mL	3.1931 mL
	30 mM	0.1064 mL	0.5322 mL	1.0644 mL	2.6609 mL