Heme Oxygenase-1-IN-1

Name: Heme Oxygenase-1-IN-1
Brand: MedChemExpress
SKU: HY-111798
Rating: 5.0 (11 reviews)

製品番号: HY-111798 純度: 99.13%: Data Sheet SDS COA 取扱説明書
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Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC₅₀ of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Heme Oxygenase-1-IN-1 構造式

CAS 番号 : 1093058-52-6

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$250	在庫あり	Estimated Time of Arrival: December 31
10 mg	$372	在庫あり	Estimated Time of Arrival: December 31
25 mg	$629	在庫あり	Estimated Time of Arrival: December 31
50 mg	$896	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1220	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 11 publication(s) in Google Scholar

Other Forms of Heme Oxygenase-1-IN-1:

Heme Oxygenase-1-IN-1 hydrochloride 在庫あり

顧客検証

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•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC₅₀ of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research^[1].

IC₅₀ & Target

IC₅₀: 0.25 μM (HO-1)^[1]

体外実験

Heme Oxygenase-1-IN-1 (0-10 µM) attenuates Dipeptidyl peptidase-4 inhibitors (DPP-4i)-induced NF-кB activation in 4T1 cells^[2].
Heme Oxygenase-1-IN-1 (0-10 µM) significantly decreases GC cell migration and invasion in parental gastric cancer cells^[3].
Heme Oxygenase-1-IN-1 significantly down-regulates HO-1 mRNA level and metastasis-associated gene expressions in GRIM-19-deficient gastric cancer cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

279.18

分子式

C₁₃H₁₅BrN₂

CAS 番号

1093058-52-6

Appearance

Solid

Color

White to off-white

SMILES

BrC1=CC=C(CCCCN2C=CN=C2)C=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (447.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5819 mL	17.9096 mL	35.8192 mL
5 mM	0.7164 mL	3.5819 mL	7.1638 mL
10 mM	0.3582 mL	1.7910 mL	3.5819 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.13%

Select Batch:

データシート (272 KB) SDS (254 KB)

COA (244 KB) HNMR (173 KB) RP-HPLC (260 KB) MS (69 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339. [Content Brief]

[2]. Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. [Content Brief]

[3]. Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5819 mL	17.9096 mL	35.8192 mL	89.5480 mL
	5 mM	0.7164 mL	3.5819 mL	7.1638 mL	17.9096 mL
	10 mM	0.3582 mL	1.7910 mL	3.5819 mL	8.9548 mL
	15 mM	0.2388 mL	1.1940 mL	2.3879 mL	5.9699 mL
	20 mM	0.1791 mL	0.8955 mL	1.7910 mL	4.4774 mL
	25 mM	0.1433 mL	0.7164 mL	1.4328 mL	3.5819 mL
	30 mM	0.1194 mL	0.5970 mL	1.1940 mL	2.9849 mL
	40 mM	0.0895 mL	0.4477 mL	0.8955 mL	2.2387 mL
	50 mM	0.0716 mL	0.3582 mL	0.7164 mL	1.7910 mL
	60 mM	0.0597 mL	0.2985 mL	0.5970 mL	1.4925 mL
	80 mM	0.0448 mL	0.2239 mL	0.4477 mL	1.1193 mL
	100 mM	0.0358 mL	0.1791 mL	0.3582 mL	0.8955 mL