Heme Oxygenase-1-IN-1 hydrochloride
Based on 12 publication(s) in Google Scholar
Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM.
For research use only. We do not sell to patients.
- Purity: 99.03%
- CAS No.: 1092851-70-1
- Formula: C13H16BrClN2
- Molecular Weight:315.64
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-10583
Y-27632 dihydrochloride
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HY-D0819
CY5-SE
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HY-10087
Navitoclax
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HY-111798
Heme Oxygenase-1-IN-1
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Ultra High Sensitivity ECL Kit
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HY-101193R
Zinc Protoporphyrin (Standard)
Publications Citing Use of MedChemExpress (MCE) Heme Oxygenase-1-IN-1 hydrochloride
More- J Clin Invest. 2024 Dec 2;134(23):e181044. [Abstract]
- Cell Death Dis. 2022 Sep 26;13(9):822. [Abstract]
- Free Radic Biol Med. 2023 Mar 27;202:46-61. [Abstract]
- Mar Drugs. 2025 Mar 12;23(3):123. [Abstract]
- Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115795. [Abstract]
- Eur J Med Res. 2026 Feb 12. [Abstract]
- Nitric Oxide. 2022 Dec 1:129:41-52. [Abstract]
- J Dent Sci. 2025 Nov 1.
- Front Oncol. 2021 Sep 24:11:728047. [Abstract]
- Front Oncol. 2021 May 26:11:679816. [Abstract]
- Cardiovasc Toxicol. 2026 May 13;26(5):48. [Abstract]
- Arch Oral Biol. 2025 Oct:178:106364. [Abstract]
Biological Activity
IC50: 0.25 μM (HO-1)[1]
Heme Oxygenase-1-IN-1 hydrochloride (0-10 µM) attenuates Dipeptidyl peptidase-4 inhibitors (DPP-4i)-induced NF-кB activation in 4T1 cells[2].
Heme Oxygenase-1-IN-1 hydrochloride (0-10 µM) significantly decreases GC cell migration and invasion in parental gastric cancer cells[3].
Heme Oxygenase-1-IN-1 hydrochloride significantly down-regulates HO-1 mRNA level and metastasis-associated gene expressions in GRIM-19-deficient gastric cancer cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1092851-70-1
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Appearance Solid
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Molecular Weight 315.64
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Formula C13H16BrClN2
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Color Light yellow to yellow
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SMILES
BrC1=CC=C(CCCCN2C=CN=C2)C=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (12)
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Journal Impact Factor
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Most Recent
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J Clin Invest
2024 Dec 2;134(23):e181044. PMID: 39621310 -
Cell Death Dis
Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation. [Abstract]2022 Sep 26;13(9):822. PMID: 36163342 -
Free Radic Biol Med
Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. [Abstract]2023 Mar 27;202:46-61. PMID: 36990300 -
Mar Drugs
Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer. [Abstract]2025 Mar 12;23(3):123. PMID: 40137309 -
Int Immunopharmacol
HMOX1 expression influence the role of macrophage in EGFR-TKI resistance of lung adenocarcinoma. [Abstract]2026 Jan 1;168(Pt 1):115795. PMID: 41205382 -
Eur J Med Res
Remimazolam alleviates acute lung injury by inhibiting ferroptosis: a multi-omics system pharmacology approach with experimental validation. [Abstract]2026 Feb 12. PMID: 41680950 -
Nitric Oxide
Polysulfides derived from the hydrogen sulfide and persulfide donor P* inhibit IL-1β-mediated inducible nitric oxide synthase signaling in ATDC5 cells: are CCAAT/enhancer-binding proteins β and δ involved in the anti-inflammatory effects of hydrogen sulfide and polysulfides?. [Abstract]2022 Dec 1:129:41-52. PMID: 36216240 -
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Front Oncol
Antidiabetic DPP-4 Inhibitors Reprogram Tumor Microenvironment That Facilitates Murine Breast Cancer Metastasis Through Interaction With Cancer Cells via a ROS-NF-кB-NLRP3 Axis. [Abstract]2021 Sep 24:11:728047. PMID: 34631556 -
Front Oncol
Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop. [Abstract]2021 May 26:11:679816. PMID: 34123848 -
Cardiovasc Toxicol
Quercetin Antagonizes Doxorubicin-Induced Cardiotoxicity via HO-1/PGC-1α-ALOX5 Axis: Arachidonic Acid Metabolism-Ferroptosis Crosstalk as a Therapeutic Target. [Abstract]2026 May 13;26(5):48. PMID: 42126728 -
Arch Oral Biol
Taiwanese green propolis suppresses NLRP3 inflammasome activation and induces Nrf2/HO-1 pathway to reduce periodontal pathogen-induced endothelial inflammation. [Abstract]2025 Oct:178:106364. PMID: 40753822
Solvent & Solubility
DMSO : 125 mg/mL (396.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (316.82 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (316.82 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339. [Content Brief]
[2]. Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. [Content Brief]
[3]. Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.1682 mL | 15.8408 mL | 31.6817 mL | 79.2042 mL |
| 5 mM | 0.6336 mL | 3.1682 mL | 6.3363 mL | 15.8408 mL | |
| 10 mM | 0.3168 mL | 1.5841 mL | 3.1682 mL | 7.9204 mL | |
| 15 mM | 0.2112 mL | 1.0561 mL | 2.1121 mL | 5.2803 mL | |
| 20 mM | 0.1584 mL | 0.7920 mL | 1.5841 mL | 3.9602 mL | |
| 25 mM | 0.1267 mL | 0.6336 mL | 1.2673 mL | 3.1682 mL | |
| 30 mM | 0.1056 mL | 0.5280 mL | 1.0561 mL | 2.6401 mL | |
| 40 mM | 0.0792 mL | 0.3960 mL | 0.7920 mL | 1.9801 mL | |
| 50 mM | 0.0634 mL | 0.3168 mL | 0.6336 mL | 1.5841 mL | |
| 60 mM | 0.0528 mL | 0.2640 mL | 0.5280 mL | 1.3201 mL | |
| 80 mM | 0.0396 mL | 0.1980 mL | 0.3960 mL | 0.9901 mL | |
| 100 mM | 0.0317 mL | 0.1584 mL | 0.3168 mL | 0.7920 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Heme Oxygenase-1-IN-1 hydrochloride Related Classifications
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