Tin protoporphyrin IX dichloride
Based on 23 publication(s) in Google Scholar
Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.
For research use only. We do not sell to patients.
- Purity: 96.2%
- CAS No.: 14325-05-4
- Formula: C34H32Cl2N4O4Sn
- Molecular Weight:750.26
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tin protoporphyrin IX dichloride
More- Antioxidants (Basel). 2022 Oct 11;11(10):2012. [Abstract]
- Clin Transl Med. 2026 Jul;16(7):e70726. [Abstract]
- CNS Neurosci Ther. 2021 Jan;27(1):82-91. [Abstract]
- J Inflamm (Lond). 2024 Jul 9;21(1):25. [Abstract]
- Respir Res. 2024 Dec 18;25(1):431. [Abstract]
- Mar Drugs. 2021 Sep 23;19(10):534. [Abstract]
- Mar Drugs. 2021 Jun 17;19(6):346. [Abstract]
- Int Immunopharmacol. 2023 Sep:122:110571. [Abstract]
- Int Immunopharmacol. 2023 Jul:120:110282. [Abstract]
- Front Pharmacol. 2021 Jan 21:11:624529. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166761. [Abstract]
- Sci Rep. 2026 Apr 24;16(1):18995. [Abstract]
- J Cell Mol Med. 2024 Feb;28(3):e18089. [Abstract]
- Lab Invest. 2022 Nov;102(11):1225-1235. [Abstract]
- J Funct Foods. August 2022, 105191.
- BMC Oral Health. 2022 Nov 24;22(1):536. [Abstract]
- J Biochem Mol Toxicol. 2024 Aug;38(8):e23792. [Abstract]
- Surgery. 2024 Aug;176(2):499-510. [Abstract]
- Transbound Emerg Dis. 2022 Sep;69(5):2697-2711. [Abstract]
- Korean J Physiol Pharmacol. 2022 Mar 1;26(2):95-111. [Abstract]
- Parkinsons Dis. 2023 Oct 10:2023:8444153. [Abstract]
- Oncol Lett. 2026 Mar 30;31(5):203. [Abstract]
- Research Square Preprint. 2022 Feb.
Biological Activity
IC50: Heme oxygenase-1 (HO-1)[1]
Tin protoporphyrin IX dichloride (20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, Tin protoporphyrin IX dichloride has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Capan-1, CD18/HPAF, PDAC cells
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Concentration:20 μM, 50 μM
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Incubation Time:24 or 72 hours
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Result:Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
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Result:Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).
Chemical Information
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CAS No. 14325-05-4
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Appearance Solid
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Molecular Weight 750.26
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Formula C34H32Cl2N4O4Sn
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Color Brown to reddish brown
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SMILES
[Cl-][Sn+4]123([N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC(O)=O)=[N]3C8=C5)[Cl-]
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Synonyms
Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (23)
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Journal Impact Factor
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Most Recent
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Antioxidants (Basel)
Melatonin Suppresses LPS-Induced Oxidative Stress in Dendritic Cells for Inflammatory Regulation via the Nrf2/HO-1 Axis. [Abstract]2022 Oct 11;11(10):2012. PMID: 36290735 -
Clin Transl Med
α7nAChR agonist GTS-21 ameliorates sepsis-induced acute kidney injury via MEF2/PGC-1α/HO-1 axis in mice. [Abstract]2026 Jul;16(7):e70726. PMID: 42333777 -
CNS Neurosci Ther
The novel Nrf2 activator CDDO-EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice. [Abstract]2021 Jan;27(1):82-91. PMID: 33280237 -
J Inflamm (Lond)
Emodin alleviates intestinal ischemia-reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation. [Abstract]2024 Jul 9;21(1):25. PMID: 38982499 -
Respir Res
Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1. [Abstract]2024 Dec 18;25(1):431. PMID: 39696251 -
Mar Drugs
Astaxanthin Provides Antioxidant Protection in LPS-Induced Dendritic Cells for Inflammatory Control. [Abstract]2021 Sep 23;19(10):534. PMID: 34677433 -
Mar Drugs
2021 Jun 17;19(6):346. PMID: 34204220 -
Int Immunopharmacol
Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice. [Abstract]2023 Sep:122:110571. PMID: 37441813 -
Int Immunopharmacol
2023 Jul:120:110282. PMID: 37224647 -
Front Pharmacol
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity. [Abstract]2021 Jan 21:11:624529. PMID: 33584308 -
Biochim Biophys Acta Mol Basis Dis
Heme induced progesterone-resistant profiling and promotion of endometriosis in vitro and in vivo. [Abstract]2023 Oct;1869(7):166761. PMID: 37247698 -
Sci Rep
Gnetum montanum extract attenuates lipopolysaccharide induced acute lung inflammation through Nrf2 and heme oxygenase 1 mediated redox modulation in macrophages. [Abstract]2026 Apr 24;16(1):18995. PMID: 42031984 -
J Cell Mol Med
Gastrodin alleviates premature senescence of vascular endothelial cells by enhancing the Nrf2/HO-1 signalling pathway. [Abstract]2024 Feb;28(3):e18089. PMID: 38146239 -
Lab Invest
Nobiletin protects retinal ganglion cells in models of ocular hypertension in vivo and hypoxia in vitro. [Abstract]2022 Nov;102(11):1225-1235. PMID: 35804043 -
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BMC Oral Health
BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells. [Abstract]2022 Nov 24;22(1):536. PMID: 36424585 -
J Biochem Mol Toxicol
Ezetimibe ketone protects against renal ischemia-reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO-1 signaling pathway. [Abstract]2024 Aug;38(8):e23792. PMID: 39082152 -
Surgery
Emodin alleviates intestinal ischemia/reperfusion-induced lung injury by upregulating HO-1 expression via PI3K/AkT pathway. [Abstract]2024 Aug;176(2):499-510. PMID: 38811326 -
Transbound Emerg Dis
2022 Sep;69(5):2697-2711. PMID: 34918880 -
Korean J Physiol Pharmacol
Metformin alleviates chronic obstructive pulmonary disease and cigarette smoke extract-induced glucocorticoid resistance by activating the nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathway. [Abstract]2022 Mar 1;26(2):95-111. PMID: 35203060 -
Parkinsons Dis
The Neuroprotective Effect of Isotetrandrine on Parkinson's Disease via Anti-Inflammation and Antiapoptosis In Vitro and In Vivo. [Abstract]2023 Oct 10:2023:8444153. PMID: 37854894 -
Oncol Lett
Lung squamous cell carcinoma downregulates haptoglobin expression to inhibit M2 macrophage ferroptosis via the hemoglobin-dependent CD163/HO-1 pathway. [Abstract]2026 Mar 30;31(5):203. PMID: 41987865 -
Solvent & Solubility
0.1 M NaOH : 12.5 mg/mL (16.66 mM; Need ultrasonic)
1M NaOH : 5 mg/mL (6.66 mM; Need ultrasonic)
DMSO : 0.5 mg/mL (0.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1M NaOH / 0.1 M NaOH | 1 mM | 1.3329 mL | 6.6644 mL | 13.3287 mL | 33.3218 mL |
| 5 mM | 0.2666 mL | 1.3329 mL | 2.6657 mL | 6.6644 mL | |
| 0.1 M NaOH | 10 mM | 0.1333 mL | 0.6664 mL | 1.3329 mL | 3.3322 mL |
| 15 mM | 0.0889 mL | 0.4443 mL | 0.8886 mL | 2.2215 mL |
Tin protoporphyrin IX dichloride Related Classifications
HY-101194 Related Classifications
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