Heme Oxygenase-1-IN-1
Based on 12 publication(s) in Google Scholar
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research.
For research use only. We do not sell to patients.
- Purity: 99.13%
- CAS No.: 1093058-52-6
- Formula: C13H15BrN2
- Molecular Weight:279.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Ferroptosis Compound Library
HY-L051
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Anti-Obesity Compound Library
HY-L087
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Mitochondrial Protection Compound Library
HY-L144
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
Publications Citing Use of MedChemExpress (MCE) Heme Oxygenase-1-IN-1
More- J Clin Invest. 2024 Dec 2;134(23):e181044. [Abstract]
- Cell Death Dis. 2022 Sep 26;13(9):822. [Abstract]
- Free Radic Biol Med. 2023 Mar 27;202:46-61. [Abstract]
- Mar Drugs. 2025 Mar 12;23(3):123. [Abstract]
- Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115795. [Abstract]
- Cardiovasc Toxicol. 2026 May 13;26(5):48. [Abstract]
- Eur J Med Res. 2026 Feb 12. [Abstract]
- Front Oncol. 2021 Sep 24:11:728047. [Abstract]
- Front Oncol. 2021 May 26:11:679816. [Abstract]
- Nitric Oxide. 2022 Dec 1:129:41-52. [Abstract]
- J Dent Sci. 2025 Nov 1.
- Arch Oral Biol. 2025 Oct:178:106364. [Abstract]
Biological Activity
IC50: 0.25 μM (HO-1)[1]
Heme Oxygenase-1-IN-1 (0-10 µM) attenuates Dipeptidyl peptidase-4 inhibitors (DPP-4i)-induced NF-кB activation in 4T1 cells[2].
Heme Oxygenase-1-IN-1 (0-10 µM) significantly decreases GC cell migration and invasion in parental gastric cancer cells[3].
Heme Oxygenase-1-IN-1 significantly down-regulates HO-1 mRNA level and metastasis-associated gene expressions in GRIM-19-deficient gastric cancer cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1093058-52-6
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Appearance Solid
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Molecular Weight 279.18
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Formula C13H15BrN2
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Color White to off-white
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SMILES
BrC1=CC=C(CCCCN2C=CN=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (12)
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Journal Impact Factor
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Most Recent
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J Clin Invest
2024 Dec 2;134(23):e181044. PMID: 39621310 -
Cell Death Dis
Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation. [Abstract]2022 Sep 26;13(9):822. PMID: 36163342 -
Free Radic Biol Med
Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. [Abstract]2023 Mar 27;202:46-61. PMID: 36990300 -
Mar Drugs
Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer. [Abstract]2025 Mar 12;23(3):123. PMID: 40137309 -
Int Immunopharmacol
HMOX1 expression influence the role of macrophage in EGFR-TKI resistance of lung adenocarcinoma. [Abstract]2026 Jan 1;168(Pt 1):115795. PMID: 41205382 -
Cardiovasc Toxicol
Quercetin Antagonizes Doxorubicin-Induced Cardiotoxicity via HO-1/PGC-1α-ALOX5 Axis: Arachidonic Acid Metabolism-Ferroptosis Crosstalk as a Therapeutic Target. [Abstract]2026 May 13;26(5):48. PMID: 42126728 -
Eur J Med Res
Remimazolam alleviates acute lung injury by inhibiting ferroptosis: a multi-omics system pharmacology approach with experimental validation. [Abstract]2026 Feb 12. PMID: 41680950 -
Front Oncol
Antidiabetic DPP-4 Inhibitors Reprogram Tumor Microenvironment That Facilitates Murine Breast Cancer Metastasis Through Interaction With Cancer Cells via a ROS-NF-кB-NLRP3 Axis. [Abstract]2021 Sep 24:11:728047. PMID: 34631556 -
Front Oncol
Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop. [Abstract]2021 May 26:11:679816. PMID: 34123848 -
Nitric Oxide
Polysulfides derived from the hydrogen sulfide and persulfide donor P* inhibit IL-1β-mediated inducible nitric oxide synthase signaling in ATDC5 cells: are CCAAT/enhancer-binding proteins β and δ involved in the anti-inflammatory effects of hydrogen sulfide and polysulfides?. [Abstract]2022 Dec 1:129:41-52. PMID: 36216240 -
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Arch Oral Biol
Taiwanese green propolis suppresses NLRP3 inflammasome activation and induces Nrf2/HO-1 pathway to reduce periodontal pathogen-induced endothelial inflammation. [Abstract]2025 Oct:178:106364. PMID: 40753822
Solvent & Solubility
DMSO : 125 mg/mL (447.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339. [Content Brief]
[2]. Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. [Content Brief]
[3]. Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5819 mL | 17.9096 mL | 35.8192 mL | 89.5480 mL |
| 5 mM | 0.7164 mL | 3.5819 mL | 7.1638 mL | 17.9096 mL | |
| 10 mM | 0.3582 mL | 1.7910 mL | 3.5819 mL | 8.9548 mL | |
| 15 mM | 0.2388 mL | 1.1940 mL | 2.3879 mL | 5.9699 mL | |
| 20 mM | 0.1791 mL | 0.8955 mL | 1.7910 mL | 4.4774 mL | |
| 25 mM | 0.1433 mL | 0.7164 mL | 1.4328 mL | 3.5819 mL | |
| 30 mM | 0.1194 mL | 0.5970 mL | 1.1940 mL | 2.9849 mL | |
| 40 mM | 0.0895 mL | 0.4477 mL | 0.8955 mL | 2.2387 mL | |
| 50 mM | 0.0716 mL | 0.3582 mL | 0.7164 mL | 1.7910 mL | |
| 60 mM | 0.0597 mL | 0.2985 mL | 0.5970 mL | 1.4925 mL | |
| 80 mM | 0.0448 mL | 0.2239 mL | 0.4477 mL | 1.1193 mL | |
| 100 mM | 0.0358 mL | 0.1791 mL | 0.3582 mL | 0.8955 mL |
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