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  3. Zinc Protoporphyrin

Zinc Protoporphyrin (Synonyms: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9)

Cat. No.: HY-101193 Purity: >98.0%
Handling Instructions

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is a normal metabolite formed in trace amounts during heme biosynthesis and used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration.

For research use only. We do not sell to patients.

Zinc Protoporphyrin Chemical Structure

Zinc Protoporphyrin Chemical Structure

CAS No. : 15442-64-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 69 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 75 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 270 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is a normal metabolite formed in trace amounts during heme biosynthesis and used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2].

Molecular Weight

626.02

Formula

C₃₄H₃₂N₄O₄Zn

CAS No.

15442-64-5

SMILES

OC(CCC1=C(C=C2[N]3=C4C(C)=C2CCC(O)=O)[N-]([Zn+2]35[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O

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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5974 mL 7.9870 mL 15.9739 mL
5 mM 0.3195 mL 1.5974 mL 3.1948 mL
10 mM 0.1597 mL 0.7987 mL 1.5974 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.99 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Product name:
Zinc Protoporphyrin
Cat. No.:
HY-101193
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