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Zinc Protoporphyrin

(Synonyms: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9)
69 Cited Publications
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Based on 69 publication(s) in Google Scholar

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial.  It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity.

For research use only. We do not sell to patients.

  • Purity: 99.87%
  • CAS No.: 15442-64-5
  • Formula: C34H32N4O4Zn
  • Molecular Weight:626.02
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Zinc Protoporphyrin Chemical Structure
    Zinc Protoporphyrin Chemical Structure
  • Experimental Validation Results for Zinc Protoporphyrin
  • Experimental Validation Results for Zinc Protoporphyrin
  • Experimental Validation Results for Zinc Protoporphyrin
  • Experimental Validation Results for Zinc Protoporphyrin
  • Experimental Validation Results for Zinc Protoporphyrin
  • Experimental Validation Results for Zinc Protoporphyrin
CAS No.: 15442-64-5
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Cell Proliferation/Viability AssayFlow CytometryWBCell Imaging/StainingHistological Imaging/StainingIn Vivo Efficacy Study
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  • Zinc Protoporphyrin Chemical Structure
    Zinc Protoporphyrin Chemical Structure
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    Zinc Protoporphyrin purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 16;13(1):9. [Abstract]

    Customer Validation
     MLO-Y4 cell viability after 48 h treatment with 75% B16F10 CM, with or without 24 h pretreatment with 10 μmol/L Fer-1, Znpp, or DMSO (control).

  • 1/16

    Zinc Protoporphyrin purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 16;13(1):9. [Abstract]

    Customer Validation
     FACS analysis using C11 BODIPY 581/591 and H2DCFDA to quantify ferroptosis in MLO-Y4 cells after 48 h treatment with 75% B16F10 CM, with or without 24 h pretreatment with 10 μmol/L Fer-1, Znpp, or DMSO (control).

  • 1/16

    Zinc Protoporphyrin purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 16;13(1):9. [Abstract]

    Customer Validation
     Western blot of MLO-Y4 cells after 48 h treatment with 75% B16F10 CM, with or without 24 h pretreatment with 10 μmol/L Znpp, or DMSO (control).

  • 1/16

    Zinc Protoporphyrin purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 16;13(1):9. [Abstract]

    Customer Validation
     Transmission electron microscopy (TEM) of MLO-Y4 cells after 48 h treatment with 75% B16F10 CM, with or without 24 h pretreatment with 10 μmol/L Znpp, or DMSO (control). Scale bars: 2500 nm (left), 1000 nm (right).

  • 1/16

    Zinc Protoporphyrin purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 16;13(1):9. [Abstract]

    Customer Validation
     H&E staining of cortical bones from mice injected with B16F10 and treated with DMSO, 1 mg/kg Fer-1, or 10 mg/kg Znpp (i.p., 13 d).

  • 1/16

    Zinc Protoporphyrin purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 16;13(1):9. [Abstract]

    Customer Validation
     µCT analysis of trabecular bone from mice injected with B16F10 and treated with DMSO, 1 mg/kg Fer-1, or 10 mg/kg Znpp (i.p., 13 d).

  • Zinc Protoporphyrin