Co(III) protoporphyrin IX chloride
Based on 1 publication(s) in Google Scholar
Co(III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) is an inducer of HO-1. Co(III) protoporphyrin IX chloride has activities such as anti-inflammation and antibacterial properties. Co(III) protoporphyrin IX chloride can also be used in the research of ischemia-reperfusion injury models.
For research use only. We do not sell to patients.
- Purity: 95%
- CAS No.: 102601-60-5
- Formula: C34H32ClCoN4O4
- Molecular Weight:655.03
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Co(III) protoporphyrin IX chloride
MoreAll Caspase Isoforms
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Biological Activity
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Caspase 3 |
Bcl-2 |
HO-1 |
Co(III) protoporphyrin IX chloride (0-25 μM; 2-16 hours) can upregulate the levels of HO-1 and Nrf2, and reduce the protein level of Bach1 in Huh-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7 cells
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Concentration:0, 0.5, 1, 5 and 10 μM
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Incubation Time:16 h
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Result:Increased the levels of HO-1 and Nrf2 in a dose-dependent manner.
Inhibited the levels of Bach1 in a dose-dependent manner.
Co(III) protoporphyrin IX chloride (5 mg/kg; intraperitoneal injection; single dose) has an improving effect in a mouse model of hepatic ischemia-reperfusion injury[3].
Co(III) protoporphyrin IX chloride (5 mg/kg; intraperitoneal injection; 6 times over 11 days) exhibits antibacterial activity in mice infected with Yersinia pestis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (25-30 g) with liver ischemia-reperfusion (I/R) injury[3]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; single dose
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Result:Significantly reduced the increase in serum levels of AST and ALT induced by I/R injury.
Alleviated hepatocellular swelling and histopathological damage.
Increased the protein expression levels of HO-1 and Bcl-2, decreased the expression of caspase 3, and reduced the percentage of apoptotic hepatocytes compared with the I/R group.
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Animal Model:C57BL/6 mice treated Yersinia pestis CO92[4]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; 24 h prior to challenge and on the day of challenge, additional treatments were provided every other day for the duration of the 10-day observation period
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Result:Improved survival, increased the time to mortality, reduced pulmonary bacterial burden, and increased HO-1 levels in the lungs compared to vehicle-treated mice.
Chemical Information
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CAS No. 102601-60-5
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Appearance Solid
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Molecular Weight 655.03
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Formula C34H32ClCoN4O4
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Color Brown to reddish brown
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SMILES
O=C(CCC1=C(C)C2=[N]3C1=CC4=C(CCC(O)=O)C(C)=C5C=C6C(C=C)=C(C)C(C=C7C(C=C)=C(C)C8=C2)=[N]6[Co+3]3([N-]78)([N-]54)[Cl-])O
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Synonyms
Protoporphyrin IX cobaltic chloride; CoPPIX-Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Virol
Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity. [Abstract]2026 Feb 17;100(2):e0165625. PMID: 41489372
Solvent & Solubility
DMSO : 62.5 mg/mL (95.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (289 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shan Y, et al. Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. FASEB J. 2006 Dec;20(14):2651-3. [Content Brief]
[2]. Drummond GS, et al. The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology. Proc Natl Acad Sci U S A. 1982 Apr;79(7):2384-8. [Content Brief]
[3]. Li J, et al. Cobalt-protoporphyrin enhances heme oxygenase 1 expression and attenuates liver ischemia/reperfusion injury by inhibiting apoptosis. Mol Med Rep. 2018 Mar;17(3):4567-4572. [Content Brief]
[4]. Willix JL, et al. Activation of Heme Oxygenase Expression by Cobalt Protoporphyrin Treatment Prevents Pneumonic Plague Caused by Inhalation of Yersinia pestis. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01819-19. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5266 mL | 7.6332 mL | 15.2665 mL | 38.1662 mL |
| 5 mM | 0.3053 mL | 1.5266 mL | 3.0533 mL | 7.6332 mL | |
| 10 mM | 0.1527 mL | 0.7633 mL | 1.5266 mL | 3.8166 mL | |
| 15 mM | 0.1018 mL | 0.5089 mL | 1.0178 mL | 2.5444 mL | |
| 20 mM | 0.0763 mL | 0.3817 mL | 0.7633 mL | 1.9083 mL | |
| 25 mM | 0.0611 mL | 0.3053 mL | 0.6107 mL | 1.5266 mL | |
| 30 mM | 0.0509 mL | 0.2544 mL | 0.5089 mL | 1.2722 mL | |
| 40 mM | 0.0382 mL | 0.1908 mL | 0.3817 mL | 0.9542 mL | |
| 50 mM | 0.0305 mL | 0.1527 mL | 0.3053 mL | 0.7633 mL | |
| 60 mM | 0.0254 mL | 0.1272 mL | 0.2544 mL | 0.6361 mL | |
| 80 mM | 0.0191 mL | 0.0954 mL | 0.1908 mL | 0.4771 mL |
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