Heme Oxygenase-1-IN-1

Name: Heme Oxygenase-1-IN-1
Brand: MedChemExpress
SKU: HY-111798
Rating: 5.0 (11 reviews)

Cat. No.: HY-111798 Pureza: 99.13%: Ficha de datos
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Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC₅₀ of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Heme Oxygenase-1-IN-1 Estructura química

No. CAS : 1093058-52-6

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 11 publication(s) in Google Scholar

Other Forms of Heme Oxygenase-1-IN-1:

Heme Oxygenase-1-IN-1 hydrochloride In-stock

11 Publications Citing Use of MCE Heme Oxygenase-1-IN-1

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•Related Small Molecules:

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Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC₅₀ of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research^[1].

IC₅₀ & Target

IC₅₀: 0.25 μM (HO-1)^[1]

In Vitro

Heme Oxygenase-1-IN-1 (0-10 µM) attenuates Dipeptidyl peptidase-4 inhibitors (DPP-4i)-induced NF-кB activation in 4T1 cells^[2].
Heme Oxygenase-1-IN-1 (0-10 µM) significantly decreases GC cell migration and invasion in parental gastric cancer cells^[3].
Heme Oxygenase-1-IN-1 significantly down-regulates HO-1 mRNA level and metastasis-associated gene expressions in GRIM-19-deficient gastric cancer cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

279.18

Fòrmula

C₁₃H₁₅BrN₂

No. CAS

1093058-52-6

Appearance

Solid

Color

White to off-white

SMILES

BrC1=CC=C(CCCCN2C=CN=C2)C=C1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (447.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5819 mL	17.9096 mL	35.8192 mL
5 mM	0.7164 mL	3.5819 mL	7.1638 mL
10 mM	0.3582 mL	1.7910 mL	3.5819 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.13%

Select Batch:

Ficha de datos (272 KB) SDS (254 KB)

COA (244 KB) HNMR (173 KB) RP-HPLC (260 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339. [Content Brief]

[2]. Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. [Content Brief]

[3]. Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5819 mL	17.9096 mL	35.8192 mL	89.5480 mL
	5 mM	0.7164 mL	3.5819 mL	7.1638 mL	17.9096 mL
	10 mM	0.3582 mL	1.7910 mL	3.5819 mL	8.9548 mL
	15 mM	0.2388 mL	1.1940 mL	2.3879 mL	5.9699 mL
	20 mM	0.1791 mL	0.8955 mL	1.7910 mL	4.4774 mL
	25 mM	0.1433 mL	0.7164 mL	1.4328 mL	3.5819 mL
	30 mM	0.1194 mL	0.5970 mL	1.1940 mL	2.9849 mL
	40 mM	0.0895 mL	0.4477 mL	0.8955 mL	2.2387 mL
	50 mM	0.0716 mL	0.3582 mL	0.7164 mL	1.7910 mL
	60 mM	0.0597 mL	0.2985 mL	0.5970 mL	1.4925 mL
	80 mM	0.0448 mL	0.2239 mL	0.4477 mL	1.1193 mL
	100 mM	0.0358 mL	0.1791 mL	0.3582 mL	0.8955 mL