House Dust Mite Extract, from D.pteronyssinus

Name: House Dust Mite Extract, from D.pteronyssinus
Brand: MedChemExpress
SKU: HY-NP159A
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製品番号: HY-NP159A: Data Sheet SDS COA 取扱説明書
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House Dust Mite Extract, from D. pteronyssinus is a house dust mite allergenic extract derived from Dermatophagoides pteronyssinus. House Dust Mite Extract, from D. pteronyssinus increases serum IgE, IgG1 and IgG2a levels, and elevates the levels of Interleukins 4, 5, 6, 10, 13 and 17. House Dust Mite Extract, from D. pteronyssinus induces significant asthmatic pathological changes. House Dust Mite Extract, from D. pteronyssinus can be used in studies related to asthma and allergic conjunctivitis.

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House Dust Mite Extract, from D.pteronyssinus 構造式

容量	価格（税別）	在庫状況	数量
600 μg	$490	在庫あり	Estimated Time of Arrival: December 31

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カスタマーレビュー

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Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

IL-6

IL-5

IL-4

IL-10

IL-13

IL-17

体内実験

House Dust Mite Extract from D.pteronyssinus (100 μg/mL; nebulization; 10 minutes per administration; 8 total administrations on Days 7, 14, 21, 28, 35, 42, 60, 61) induces significant asthmatic pathology in male BALB/c mice, including elevated airway hyperresponsiveness, inflammatory cell infiltration, immunoglobulin production, cytokine release, bronchial thickening, collagen deposition, and MUC5AC expression, all significantly greater than PBS control levels^[1].
House Dust Mite Extract, from D.pteronyssinus (10-500 μg; i.p.; days 1 and 8; absorbed on 2.0 mg aluminum hydroxide; 500 μg; topical instillation in each eye; days 15, 17, 19) induces allergic conjunctivitis in BALB/c mice, with 10 μg as the optimal intraperitoneal sensitization dose, resulting in the highest total IgE levels, IL-5 production, and proportion of conjunctival CD4⁺ST2⁺ T cells with intracellular IL-5^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c (male, 5-week-old)^[1]
Dosage:	100 μg/mL
Administration:	nebulization; 10 minutes per administration; 8 total administrations on Days 7, 14, 21, 28, 35, 42, 60, 61
Result:	Showed significantly higher airway hyperresponsiveness (Penh V) than PBS control at all tested methacholine concentrations (3.1, 6.25, 12.5, 25, 50 mg/mL). Increased total cell, eosinophil, neutrophil, lymphocyte, and macrophage counts in bronchoalveolar lavage fluid compared to PBS control (P < 0.01). Elevated serum IgE, IgG1, and IgG2a levels compared to PBS control (P < 0.05). Increased bronchoalveolar lavage fluid levels of IL-4, IL-5, IL-6, IL-10, IL-13, and IL-17 compared to PBS control (P < 0.05). Increased splenocyte levels of IL-4, IL-5, IL-6, IL-10, IL-13, and IL-17 compared to PBS control (P < 0.05). Caused significantly thicker bronchial mucosa, increased collagen deposition, and higher percentage of PAS-positive cells in lung tissue compared to PBS control (P < 0.01). Increased MUC5AC protein and mRNA expression in lung tissue compared to PBS control (P < 0.01).

Animal Model:	BALB/c (female, 8-week-old, allergic conjunctivitis model via intraperitoneal sensitization followed by topical ocular challenge)^[2]
Dosage:	10 μg (i.p. sensitization); 100 μg (i.p. sensitization); 500 μg (i.p. sensitization); 500 μg (topical ocular challenge)
Administration:	i.p.; days 1 and 8; absorbed on 2.0 mg aluminum hydroxide; topical instillation in each eye; days 15, 17, 19
Result:	Exhibited mean clinical scores of 6 to 7, with symptoms including eye frowning, discharge, and hyperemia (no significant difference between HDM groups). Showed significantly elevated total serum IgE levels: ~800 ng/mL (10 μg i.p. group), ~350 ng/mL (100 μg group), ~250 ng/mL (500 μg group), compared to controls. Displayed significantly elevated HDM-specific IgE (OD 450 nm): ~0.6 (10 μg group), ~0.4 (100 μg group), ~0.3 (500 μg group), compared to controls. Increased cervical lymphocyte proliferation after HDM stimulation: S-phase lymphocyte populations rose from 4.7% to 13.2% (10 μg group), 3.2% to 11.5% (100 μg group), and 3.3% to 12.5% (500 μg group); S-phase CD4+ T-cell populations rose from 5.0% to 11.7% (10 μg group), 1.4% to 3.3% (100 μg group), and 3.4% to 15.5% (500 μg group). Showed significantly elevated IL-4 and IL-5 levels in cervical lymphocyte supernatants after HDM stimulation; IL-5 levels reached ~45 pg/mL in the 10 μg group, significantly higher than other HDM groups. Induced significant conjunctival infiltration of eosinophils (~6-8 cells per slide) and mast cells (~10-14 cells per slide) compared to controls. Had the highest proportion of conjunctival CD4+ST2+ T cells (17.1%) and the highest proportion of these cells with intracellular IL-5 (82.4%) in the 10 μg group, significantly elevated compared to controls.

Appearance

Solid

Color

Light brown to brown

SMILES

[House Dust Mite Extract, from D.pteronyssinus]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

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データシート (270 KB) SDS (251 KB)

COA (231 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Kim EM, et al. The storage mite Tyrophagus putrescentiae induces greater lung inflammation than house dust mites in mice. Parasites Hosts Dis. 2024;62(3):365-377. [Content Brief]

[2]. Lee YJ, et al. Development of Allergic Conjunctivitis Induced by House Dust Mite Extract From Dermatophagoides pteronyssinus. Invest Ophthalmol Vis Sci. 2016;57(4):1773-1781. [Content Brief]