2. Inhibitory Antibodies
  3. Isotype Control Antibodies
  4. Human IgG1 kappa, Isotype Control

Human IgG1 kappa, Isotype Control 

Cat. No.: HY-P99001 Purity: 99.71%
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Human IgG1 kappa, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1 kappa antibody.

For research use only. We do not sell to patients.

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Customer Review

Based on 14 publication(s) in Google Scholar

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Human IgG1 kappa, Isotype Control Related Antibodies

Top Publications Citing Use of Products

    Human IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2025 Oct 17.  [Abstract]

    A single mesodermal tumor was injected into mesodermal CAR-T cells, and the following treatments were administered: untreated group, daratumumab (0.5 or 10 μg/ml) treatment group, or IgG isotype control antibody (10 μg/ml IgG) treatment group. The change in T cell area over time was quantitatively analyzed.

    Human IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Front Immunol. 2025 May 21:16:1572676.  [Abstract]

    Cytotoxicity of NK cells with IgG (10 μg/mL) or anti-PSMA antibody against PCa tissue-derived organoid at E/T ratio of 5:1 after 2 h and 6h coculture measured using LDH assay.

    Human IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 24.

    Isotype control antibodies (IgG4κ and IgG1κ) were used as negative controls to demonstrate that pembrolizumab (anti-PD-1) and fragifilimab (anti-GITR) showed no inhibition of tumor growth in the HU-CD34+ T188 PDOX mouse model.

    Human IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Apr 10;12(1):24.  [Abstract]

    Representative images display capillary-like structures formed by OPLL-derived ligament cells on Matrigel under distinct conditions : unstimulated (Blank), IgG isotype control (250 μg/ml; 4-6 h), and Bevacizumab .

    Human IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2023 Aug 1:568:216300.  [Abstract]

    Tumor volumes at various times (horizontal axis) after tumor implantation in the control and treatment groups, including NK, NK + IgG (10 mg/kg; ip), and NK + TIGIT blocker groups.

    Human IgG1 kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2023 Aug 1:568:216300.  [Abstract]

    The killing rate of NK cells against C4-2 cells in the NK, NK + IgG (10 μg/ml), NK + vibostolimab, NK + relatlimab and NK + vibostolimab + relatlimab treatment groups was determined using the CCK-8 assay, and the results were obtained after 2 hours and 6 hours of co-culture.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Human IgG1 kappa, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1 kappa antibody[1].

    Isotype

    Human IgG1 kappa (native Fc)
    In Vitro

    Human IgG1 kappa, Isotype Control is often used as the experimental negative control. Human IgG1 kappa, Isotype Control exhibits similar structure and biological properties as human immunoglobulin G1 (IgG1), but lacks specific antigen binding ability[2].
    Human IgG1 kappa, Isotype Control (10 μg/mL, 2-6 h) exhibits no promoting effect on the killing activity of NK cells against CRPC cells or normal prostate epithelial cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Human IgG1 kappa, Isotype Control Related Antibodies
    In Vivo

    Human IgG1 kappa, Isotype Control (10 mg/kg, ip, every 4 days for 4 doses) exhibits no antitumor activity, and has no effects on the mice survival duration in C4-2- or 22RV1 xenograft models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    142.68 kDa

    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Human IgG1 kappa, Isotype Control]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation

    Purity: 99.71%

    SDS (251 KB)

    COA (232 KB) SDS-PAGE (68 KB) SEC-HPLC (168 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Human IgG1 kappa, Isotype Control Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Human IgG1 kappa, Isotype ControlOthershumanizedmonoclonalantibodyIgG1κInhibitorinhibitorinhibit

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