Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)  (Synonyms: HSA (Cell culture grade, Endotoxin<0.125 EU/mg))

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO⁻) in the vascular wall, contributing to the reduction of blood pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can be used for in vitro cell culture^[1][2][3].
This product is human serum albumin recombinantly expressed in an Escherichia coli expression system.

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) binds to the saturated 12 carbon acyl chain component of GML with high affinity (K_d = 1.4 μM) and this interaction affects the concentration of HSA-GML complexes in solution^[3].
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (1%, 0-15 min) partially rescues downstream phosphorylation of AKT in GML treated human T cells ^[3].
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (1%) relieves the disruption of LAT, PLC-γ1, and AKT clustering by GML, restoring the formation of signaling protein microclusters at the plasma membrane in activated primary human T cells^[3]. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (0.2-2%) restores cytokine production (IFN-γ, IL-2, IL-10, TNF-α) in GML treated human T cells^[3].
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) has many physiological functions, such as the regulation of both colloid osmotic pressure and capillary membrane permeability, ligand binding and transport, free radical scavenging, as well as anti-oxidant and circulatory protective properties^[2].
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is a valuable biomarker of many diseases, including cancer, rheumatoid arthritis, ischemia, post-menopausal obesity, severe acute graft-versus-host disease, and diseases that need monitoring of the glycemic control^[2].
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can be used for biotechnological applications, including implantable biomaterials, surgical adhesives and sealants, biochromatography, ligand trapping, and fusion proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

70024-90-7

Solid

White to off-white

[Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)]

Room temperature in continental US; may vary elsewhere.

• [1]. Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med. 2018 Jun;52:8-12.  [Content Brief]

  [2]. Fanali G, et al. Human serum albumin: from bench to bedside. Mol Aspects Med. 2012 Jun;33(3):209-90.  [Content Brief]

  [3]. Zhang MS, et al. Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function. PLoS One. 2016;11(10):e0165083. Published 2016 Oct 20.  [Content Brief]