HX600 

HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity^[1].

HX600 (100-1000 μM; 24 h) is not directly neuroprotective against glutamate exposure^[1].
HX600 (1 μM; 24 h) inhibits the expression of inflammatory mediators in primary microglia and prevents inflammation induced neuronal death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HX600 (60 mg/kg; p.o.; every 24h) reduces ischemic damage and alleviates motor deficits in permanent ischemia model and Iba-1, phospho-p38 and TREM-2 immunoreactivities in the ischemic brain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

438.56

C₂₉H₃₀N₂O₂

172705-89-4

Solid

Yellow to orange

O=C(O)C1=CC=C(C2=NC3=CC=CC=C3N(C)C4=CC5=C(C(C)(C)CCC5(C)C)C=C42)C=C1

Room temperature in continental US; may vary elsewhere.

• [1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71.  [Content Brief]

  [2]. Hiroki Umemiya, et al. Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233(1):121-5.  [Content Brief]