2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. ICI 162846

ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU.

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ICI 162846

ICI 162846 Estructura química

No. CAS : 84545-30-2

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1 mg Obtener un presupuesto 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
5 mg Obtener un presupuesto 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
10 mg Obtener un presupuesto 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
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ICI 162846 Related Antibodies

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Descripciòn

ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU[1][2].

IC50 & Target[1]

H2 Receptor

 

In Vivo

ICI 162846 (10 mg/kg, p.o., twice daily for 5 days) reduces the incidence of CDU and inhibits acid production accompanied by an increase in the secretion of histamine in induced CDU models of CFLP mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CFLP mice were irradiated to the lower mediastinum to induce CDU[2].
Dosage: 10 mg/kg, twice daily for 5 days
Administration: Oral gavage (p.o.)
Result: Reduced the incidence of CDU.
Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.
Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.
Peso molecular

306.29

Fòrmula

C11H17F3N6O
No. CAS
SMILES

O=C(N)CCCCN1N=C(NC(NCC(F)(F)F)=N)C=C1
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Room temperature in continental US; may vary elsewhere.
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ICI 162846 Related Classifications

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Keywords:

ICI 16284684545-30-2ICI162846ICI-162846Histamine Receptororally activeCDUInhibitorinhibitorinhibit

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Nombre del producto:
ICI 162846
Cat. No.:
HY-101234
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