84545-30-2
84545-30-2
Chemical Structure
ICI 162846
- CAS No.: 84545-30-2
- Formula:C11H17F3N6O
- Molecular Weight:306.29
IUPAC Name: 5-(3-(3-(2,2,2-trifluoroethyl)guanidino)-1H-pyrazol-1-yl)pentanamide
InChIKey: ALCSGJCIESECFD-UHFFFAOYSA-N
SMILES: O=C(N)CCCCN1N=C(NC(NCC(F)(F)F)=N)C=C1
Biological Activity: ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU[1][2].
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ICI 162846 | ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU. | |||||||||||||||||||||
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References
- [1]. Wilson JA, et al. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9. [Content Brief]
- [2]. Gompertz RH, et al. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33(1-2):161-3. [Content Brief]
Keywords
