ICI 162846
ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU.
For research use only. We do not sell to patients.
- CAS No.: 84545-30-2
- Formula: C11H17F3N6O
- Molecular Weight:306.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
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H2 Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CFLP mice were irradiated to the lower mediastinum to induce CDU[2].
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Dosage:10 mg/kg, twice daily for 5 days
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Administration:Oral gavage (p.o.)
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Result:Reduced the incidence of CDU.
Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.
Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.
Chemical Information
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CAS No. 84545-30-2
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Molecular Weight 306.29
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Formula C11H17F3N6O
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SMILES
O=C(N)CCCCN1N=C(NC(NCC(F)(F)F)=N)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wilson JA, et al. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9. [Content Brief]
[2]. Gompertz RH, et al. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33(1-2):161-3. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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