2. Immunology/Inflammation
  3. NO Synthase
  4. Idesin

Idesin is a compound found in the fruits of Idesia polycarpa. Idesin inhibits LPS (HY-D1056)-induced nitric oxide production with mild cytotoxicity.

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Idesin

Idesin 화학구조

CAS No. : 20331-85-5

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Idesin Related Antibodies

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제품 설명

Idesin is a compound found in the fruits of Idesia polycarpa. Idesin inhibits LPS (HY-D1056)-induced nitric oxide production with mild cytotoxicity[1].

Cellular Effect
Cell Line Type Value Description References
3T3-L1 IC50
127.2 3
Compound: 6
Antiadipogenic activity in mouse 3T3L1 cells assessed as differentiation of preadipocytes to adipocytes after 8 days by spectrophotometry
Antiadipogenic activity in mouse 3T3L1 cells assessed as differentiation of preadipocytes to adipocytes after 8 days by spectrophotometry
[PMID: 23628332]
In Vitro

Idesin (Compound 4) (1-100 μM; 25 h) significantly inhibits LPS (HY-D1056)-induced NO production in BV2 microglial cells, with mild cytotoxicity at 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Idesin Related Antibodies

Cell Viability Assay[1]

Cell Line: BV2 mouse microglial cells (LPS-stimulated)
Concentration: 1 μM, 10 μM, 100 μM
Incubation Time: 25 h total (1 h pre-treatment + 24 h co-incubation with LPS)
Result: Reduced nitrite levels to 7.0 ± 0.1 μM and resulted in 87.2 ± 4.2% cell viability at 1 μM.
Reduced nitrite levels to 5.5 ± 0.3 μM and resulted in 97.6 ± 6.3% cell viability at 10 μM.
Reduced nitrite levels to 4.9 ± 0.5 μM and resulted in 90.7 ± 6.8% cell viability at 100 μM.
분자량

302.28

화학식

C13H18O8
CAS No.
SMILES

OCC(C=CC=C1O)=C1O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Idesin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idesin20331-85-5NO SynthaseNitric oxide synthasesNOSnitric oxideIdesia polycarpamicrogliaBV2 microglial cellslipopolysaccharideInhibitorinhibitorinhibit

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Idesin
Cat. No.:
HY-N18031
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