2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Immepip

Immepip is a H3 agonist. Immepip can reduce cortical histamine release. Immepip can be used for the research of neurological diseases.

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Immepip

Immepip Estructura química

No. CAS : 151070-83-6

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1 mg En stock
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10 mg   Obtener un presupuesto  

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Immepip Related Antibodies

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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Descripciòn

Immepip is a H3 agonist. Immepip can reduce cortical histamine release. Immepip can be used for the research of neurological diseases[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
0.67 nM
Compound: 3
Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding
Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding
[PMID: 20690643]
CHO-K1 EC50
0.67 nM
Compound: 2, Immepip
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintillation counting
Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintillation counting
[PMID: 20541426]
In Vivo

Immepip (i.p.; 5, 10 mg/kg) markedly reduces cortical histamine release, but only weakly promotes sleep in the rat[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 5, 10 mg/kg
Administration: Intraperitoneally
Result: Significantly modulated brain histamine release and slight, albeit significant, decreased in sleep onset latency.
Peso molecular

165.24

Fòrmula

C9H15N3
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

C1(CC2=CN=CN2)CCNCC1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (302.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0518 mL 30.2590 mL 60.5180 mL
5 mM 1.2104 mL 6.0518 mL 12.1036 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.0518 mL 30.2590 mL 60.5180 mL 151.2951 mL
5 mM 1.2104 mL 6.0518 mL 12.1036 mL 30.2590 mL
10 mM 0.6052 mL 3.0259 mL 6.0518 mL 15.1295 mL
15 mM 0.4035 mL 2.0173 mL 4.0345 mL 10.0863 mL
20 mM 0.3026 mL 1.5130 mL 3.0259 mL 7.5648 mL
25 mM 0.2421 mL 1.2104 mL 2.4207 mL 6.0518 mL
30 mM 0.2017 mL 1.0086 mL 2.0173 mL 5.0432 mL
40 mM 0.1513 mL 0.7565 mL 1.5130 mL 3.7824 mL
50 mM 0.1210 mL 0.6052 mL 1.2104 mL 3.0259 mL
60 mM 0.1009 mL 0.5043 mL 1.0086 mL 2.5216 mL
80 mM 0.0756 mL 0.3782 mL 0.7565 mL 1.8912 mL
100 mM 0.0605 mL 0.3026 mL 0.6052 mL 1.5130 mL
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Immepip Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Immepip151070-83-6Histamine ReceptorH3cortical histamineneurological diseasesInhibitorinhibitorinhibit

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Nombre del producto:
Immepip
Cat. No.:
HY-101321
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