2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis Autophagy
  3. Fungal Reactive Oxygen Species (ROS) Apoptosis Autophagy
  4. Iturin A

Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity.

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Iturin A

Iturin A Chemische Struktur

CAS. Nr. : 52229-90-0

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Based on 1 publication(s) in Google Scholar

Iturin A Related Antibodies

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1 Publications Citing Use of MCE Iturin A

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Beschreibung

Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity[1][2].

In Vitro

Iturin A (5-250 µg/mL;12 h) significantly inhibits Fusarium graminearum conidial activity at a concentration of 5 µg/mL, and completely inhibits conidial germination at 50 µg/mL[1].
Iturin A (0-100 μM; 48 h) inhibits cell growth, induces cell cycle arrest, ROS outburst, apoptosis and autophagy in HepG2 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Iturin A Related Antibodies

Cell Viability Assay[2]

Cell Line: HepG2
Concentration: 5, 10, 25, 50, 75 and 100 μM
Incubation Time: 48 h
Result: Inhibited the growth of HepG2 cells in a concentration dependent manner.
In Vivo

Iturin A (3 mg/kg; 15 days) has antitumor activity in a mouse model of liver cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HepG2 cells treated female BALB/c nude mice aged 4 weeks old[2]
Dosage: 3 mg/kg
Administration: 15 days
Result: Significantly inhibited tumor growth.
Induced apoptosis and autophagy of tumor cells.
Improved the tumor immune microenvironment.
Had no significant influence on body weight, food intake, and viscera index in mice
Interfered with the liver function of mice, but has no significant effect on the renal function.
Was safe to kidney and spleen.
CAS. Nr.
Appearance

Solid

Color

White to off-white

Sequence

cyclo[D-Asn-Gln-Pro-D-Asn-Ser-Unk-Asn-D-Tyr]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

Ethanol : 5 mg/mL (Need ultrasonic)

H2O : 1 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 98.53%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iturin A52229-90-0FungalReactive Oxygen Species (ROS)ApoptosisAutophagyHepG2liver cancer modelInhibitorinhibitorinhibit

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