2. Epigenetics
  3. Histone Acetyltransferase
  4. JG-2016

JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1) with an IC50 of 14.8 μM. JG-2016 can inhibit the growth of multiple tumor cells and has anti-tumor activity.

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JG-2016

JG-2016 화학구조

CAS No. : 2887480-87-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

JG-2016 Related Antibodies

Top Publications Citing Use of Products

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1) with an IC50 of 14.8 μM. JG-2016 can inhibit the growth of multiple tumor cells and has anti-tumor activity[1].

Cellular Effect
Cell Line Type Value Description References
HCC1806 EC50
10.4 μM
Compound: 24a; JG-2016
Cytotoxicity against human HCC1806 cells assessed as inhibition of cell growth by resazurin dye based fluorescence analysis
Cytotoxicity against human HCC1806 cells assessed as inhibition of cell growth by resazurin dye based fluorescence analysis
[PMID: 37027002]
In Vitro

JG-2016 (0.01-100 μM) can inhibit the growth of multiple cancer cell lines. The EC50 values in HCC1806, A549, and HCC1937 are 10.4 μM, 1.9 μM, and 29.8 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JG-2016 Related Antibodies
In Vivo

JG-2016 (50-100 mg/kg; intraperitoneal injection; once every three days; a total of six times) can significantly inhibit tumor growth in the A549 tumor-bearing mouse model, and the inhibitory effect is more pronounced at higher doses[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

376.84

화학식

C18H21ClN4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)N=C2N(CCOCC(C)C)C3=CC(CC)=C(Cl)C=C3N=C2C1=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (265.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6536 mL 13.2682 mL 26.5365 mL
5 mM 0.5307 mL 2.6536 mL 5.3073 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 98.44%

SDS (251 KB)

COA (253 KB) HNMR (144 KB) RP-HPLC (237 KB) MS (200 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6536 mL 13.2682 mL 26.5365 mL 66.3412 mL
5 mM 0.5307 mL 2.6536 mL 5.3073 mL 13.2682 mL
10 mM 0.2654 mL 1.3268 mL 2.6536 mL 6.6341 mL
15 mM 0.1769 mL 0.8845 mL 1.7691 mL 4.4227 mL
20 mM 0.1327 mL 0.6634 mL 1.3268 mL 3.3171 mL
25 mM 0.1061 mL 0.5307 mL 1.0615 mL 2.6536 mL
30 mM 0.0885 mL 0.4423 mL 0.8845 mL 2.2114 mL
40 mM 0.0663 mL 0.3317 mL 0.6634 mL 1.6585 mL
50 mM 0.0531 mL 0.2654 mL 0.5307 mL 1.3268 mL
60 mM 0.0442 mL 0.2211 mL 0.4423 mL 1.1057 mL
80 mM 0.0332 mL 0.1659 mL 0.3317 mL 0.8293 mL
100 mM 0.0265 mL 0.1327 mL 0.2654 mL 0.6634 mL
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JG-2016 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JG-20162887480-87-5JG2016JG 2016Histone AcetyltransferaseHATsHATInhibitorinhibitorinhibit

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상품명:
JG-2016
Cat. No.:
HY-154944
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

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