2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS inhibitor-13

KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers.

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KRAS inhibitor-13

KRAS inhibitor-13 Estructura química

No. CAS : 2230873-96-6

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KRAS inhibitor-13 Related Antibodies

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Descripciòn

KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

IC50 & Target[1]

KRas G12C

0.883 μM (IC50)

Peso molecular

479.95

Fòrmula

C25H19ClFN3O2S
No. CAS
SMILES

C=CC(N1[C@]2([H])[C@@](CC1)([H])N(C3=C4C(C(F)=C(C5=CC(O)=CC6=C5C=CC=C6)C(Cl)=C4)=NS3)C2)=O
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Room temperature in continental US; may vary elsewhere.
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KRAS inhibitor-13 Related Classifications

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Keywords:

KRAS inhibitor-132230873-96-6KRAS inhibitor13KRAS inhibitor 13RasMIA PaCA-2A549anticancerp-ERKpancreaticcolorectallung cancerInhibitorinhibitorinhibit

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Nombre del producto:
KRAS inhibitor-13
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HY-146543
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