2230873-96-6
Chemical Structure
KRAS inhibitor-13
- CAS No.: 2230873-96-6
- Formula:C25H19ClFN3O2S
- Molecular Weight:479.95
IUPAC Name: 1-((1S,5S)-6-(5-chloro-7-fluoro-6-(3-hydroxynaphthalen-1-yl)benzo[c]isothiazol-3-yl)-2,6-diazabicyclo[3.2.0]heptan-2-yl)prop-2-en-1-one
InChIKey: URKYROWBWZUPML-PMACEKPBSA-N
SMILES: C=CC(N1[C@]2([H])[C@@](CC1)([H])N(C3=C4C(C(F)=C(C5=CC(O)=CC6=C5C=CC=C6)C(Cl)=C4)=NS3)C2)=O
Biological Activity: KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
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KRAS inhibitor-13 | KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers. | |||||||||||||||||||||
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Keywords
