2. Autophagy
  3. Atg8/LC3 Autophagy
  4. LC3B recruiter 2

LC3B recruiter 2 (34R) is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), which directly binds to LC3B. LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 (HY-10008) through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex (with inhibitory effects on both). Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity.

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LC3B recruiter 2

LC3B recruiter 2 構造式

CAS 番号 : 380636-64-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 107 在庫あり
Solution
10 mM * 1 mL in DMSO USD 107 在庫あり
Solid
5 mg $98 在庫あり
10 mg $156 在庫あり
25 mg $312 在庫あり
50 mg $500 在庫あり
100 mg $800 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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LC3B recruiter 2 関連抗体

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製品説明

LC3B recruiter 2 (34R) is an LC3B recruiter and a component of the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), which directly binds to LC3B. LC3B recruiter 2 binds to CDK9 inhibitor SNS-032 (HY-10008) through a linker, forming an ATTEC that targets the degradation of the CDK9 and Cyclin T1 complex (with inhibitory effects on both). Therefore, LC3B recruiter 2 exerts activity through the LC3B-dependent autophagy-lysosome pathway, interfering with the cell cycle of cancer cells, thus exhibiting antitumor activity[1].

分子量

224.64

分子式

C10H9ClN2O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCN1C(NC2=CC(Cl)=CC=C2C1=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 35 mg/mL (155.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4516 mL 22.2578 mL 44.5157 mL
5 mM 0.8903 mL 4.4516 mL 8.9031 mL
10 mM 0.4452 mL 2.2258 mL 4.4516 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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体積 （開始）

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4516 mL 22.2578 mL 44.5157 mL 111.2892 mL
5 mM 0.8903 mL 4.4516 mL 8.9031 mL 22.2578 mL
10 mM 0.4452 mL 2.2258 mL 4.4516 mL 11.1289 mL
15 mM 0.2968 mL 1.4839 mL 2.9677 mL 7.4193 mL
20 mM 0.2226 mL 1.1129 mL 2.2258 mL 5.5645 mL
25 mM 0.1781 mL 0.8903 mL 1.7806 mL 4.4516 mL
30 mM 0.1484 mL 0.7419 mL 1.4839 mL 3.7096 mL
40 mM 0.1113 mL 0.5564 mL 1.1129 mL 2.7822 mL
50 mM 0.0890 mL 0.4452 mL 0.8903 mL 2.2258 mL
60 mM 0.0742 mL 0.3710 mL 0.7419 mL 1.8548 mL
80 mM 0.0556 mL 0.2782 mL 0.5564 mL 1.3911 mL
100 mM 0.0445 mL 0.2226 mL 0.4452 mL 1.1129 mL
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LC3B recruiter 2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC3B recruiter 2380636-64-6Atg8/LC3AutophagyAutophagy-related 8;Inhibitorinhibitorinhibit

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製品名:
LC3B recruiter 2
製品番号:
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