2. GPCR/G Protein
  3. GnRH Receptor
  4. Linzagolix

Linzagolix  (Synonyms: KLH-2109; OBE-2109)

Cat. No.: HY-109093 Pureza: 99.68%
COA
SDS
Instrucciones de manejo Technical Support

Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research.

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Linzagolix

Linzagolix Estructura química

No. CAS : 935283-04-8

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
1 mg En stock
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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Descripciòn

Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research[1][2][3].

In Vivo

Linzagolix (50 mg/kg) reduces cyst volume in a rat model of endometriosis[1].
Lindagolix reduces serum luteinizing hormone and testosterone levels in male rats and dogs with normal or BPH models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Endometriosis model rat[1]
Dosage: 50 mg/kg
Administration:
Result: Reduced cyst volume.
Ensayo clínico
Peso molecular

508.42

Fòrmula

C22H15F3N2O7S
No. CAS
Appearance

Solid

Color

White to light brown

SMILES

O=C(C(SC=C1NC(N2C3=C(F)C=C(OC)C(OCC4=C(C(F)=CC=C4OC)F)=C3)=O)=C1C2=O)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 125 mg/mL (245.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9669 mL 9.8344 mL 19.6688 mL
5 mM 0.3934 mL 1.9669 mL 3.9338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.68%

SDS (252 KB)

COA (250 KB) LCMS (94 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9669 mL 9.8344 mL 19.6688 mL 49.1719 mL
5 mM 0.3934 mL 1.9669 mL 3.9338 mL 9.8344 mL
10 mM 0.1967 mL 0.9834 mL 1.9669 mL 4.9172 mL
15 mM 0.1311 mL 0.6556 mL 1.3113 mL 3.2781 mL
20 mM 0.0983 mL 0.4917 mL 0.9834 mL 2.4586 mL
25 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.9669 mL
30 mM 0.0656 mL 0.3278 mL 0.6556 mL 1.6391 mL
40 mM 0.0492 mL 0.2459 mL 0.4917 mL 1.2293 mL
50 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.9834 mL
60 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8195 mL
80 mM 0.0246 mL 0.1229 mL 0.2459 mL 0.6146 mL
100 mM 0.0197 mL 0.0983 mL 0.1967 mL 0.4917 mL
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Linzagolix Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linzagolix935283-04-8KLH-2109 OBE-2109KLH2109KLH 2109OBE2109OBE 2109OBE-2109GnRH ReceptorGonadotropin releasing hormone receptorGNRHRuterine fibroidsendometriosisadenomyosisInhibitorinhibitorinhibit

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Nombre del producto:
Linzagolix
Cat. No.:
HY-109093
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