Liproxstatin-1 hydrochloride

Name: Liproxstatin-1 hydrochloride
Brand: MedChemExpress
SKU: HY-12726A
Rating: 5.0 (232 reviews)

製品番号: HY-12726A 純度: 99.31%: Data Sheet SDS COA 取扱説明書
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Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 2250025-95-5

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 105	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 105	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$96	在庫あり	Estimated Time of Arrival: December 31
10 mg	$168	在庫あり	Estimated Time of Arrival: December 31
25 mg	$336	在庫あり	Estimated Time of Arrival: December 31
50 mg	$500	在庫あり	Estimated Time of Arrival: December 31
100 mg	$680	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 232 publication(s) in Google Scholar

Other Forms of Liproxstatin-1 hydrochloride:

Liproxstatin-1 在庫あり
Liproxstatin-1-¹³C₆ お問い合わせ
Liproxstatin-1-¹⁵N お問い合わせ

顧客検証

Flow Cytometry

In Vivo Imaging

RT-PCR

Cell Proliferation/Viability Assay

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Feb 3:80:103528. [Abstract]; Tp53-deficient ID8 tumor-bearing mice were administered with Niraparib (50 mg/kg) from day 6, and administered with Lipro-1 (10 mg/kg, intraperitoneally, a single dose) and SSO (sulfosuccinimidyl oleate) (50 mg/kg, intragastrically, a single dose) from day 3. Representative actual or bioluminescent images of mice after a 3-week treatment.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Nov 5:78:103419. [Abstract]; Cell viability of the control NCI–H358, Calu-1, NCI–H23, MIA PaCa-2 and the corresponding resistant cell lines after 24 h of treatment with the indicated compounds. 2 μM liproxstatin-1 (Lip-1), 10 μM sorafenib or 10 μM lapatinib was used to treat NCI–H358, NCI–H23 and MIA PaCa-2 cells, while Calu-1 cells were treated with 2 μM liproxstatin-1 (Lip-1), 3 μM sorafenib or 10 μM lapatinib (n = 3).

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec 5:79:103460. [Abstract]; 143B and SJSA-1 cells were treated with SFN with or without Lip-1 (1 μM) for 48 h, and cell viability was evaluated.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Jul 2;14(10):4090-4106. [Abstract]; Liproxstatin 1 (Lip-1) (48 h) largely reverses the cytotoxicity of ferroptosis inducers enhanced by p62 knockdown in Hela cells.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 May 23:73:103207. [Abstract]; Cell survival of 5FU-R cells treated with a gradient concentration of PUFAs and 10 μM ferrostatin-1, or 10 μM liproxstatin-1 for 24 h.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Dec 5:480:135952. [Abstract]; Liproxstatin-1 (100 nM; 50 h) alleviates the decrease in O-GlcNAcylation levels and ferroptosis-related proteins in AML12 cells caused by DON (48 h) exposure.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: MedComm. 2024 Apr 4;5(4):e520. [Abstract]; Antiferroptosis treatment repressed the development of AS in vivo. Normal group: normal diet; HFD group: HFD for 3 months; HFD + ferrostatin‐1 group: HFD accompanied by ferrostatin‐1 treatment (1 mg/kg, twice a day, i.p.); HFD + liproxstatin‐1 group: HFD accompanied by liproxstatin‐1 treatment (10 mg/kg, twice a day, i.p.). IHC of 4‐HEN (ferroptosis marker) in aortic sinus.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Jan 17;10(1):34. [Abstract]; After pretreatment with Fer-1 (10 μM), Lip-1 (2 μM), or DFO (10 μM) for 1 hour, the cells were treated with GLU or NMDA (1 mM) for 24 hours, and then flow cytometry was performed.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Dec;10(36):e2303812. [Abstract]; Cell viability of HEC-1A cells transfected with sh‐PRMT3 and treated with erastin in the absence or presence of liproxstatin‐1 (400 nM), ZVAD‐FMK (10 µM), 3‐methyladenine (1 mM) or necrosulfonamide (10 µM) for 48 h.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Jan:304:122430.; Liproxstatin-1 (1 μM). The concentration-dependent cytotoxicity of LysoCOS7, LysoRaw and LysoNeu in the presence of various inhibitors.

: Liproxstatin-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2019 Nov 5;519(2):240-245. [Abstract]; The ROS and inflammatory cytokines levels increase in acute RILI. The serum levels of inflammatory cytokines increase in RILI. Elisa was used to measure the levels of inflammatory cytokines (TNF-a, IL-6, IL-10 and TGF-b1) at day 15, day 30 and day 60.

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC₅₀=22 nM)^[1].

体外実験

Liproxstatin-1 shows antiferroptotic activity with an IC₅₀ of approximately 38 nM in mouse embryonic fibroblasts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4^-/- kidney and in an ischaemia/reperfusion-induced tissue injury model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

377.31

分子式

C₁₉H₂₂Cl₂N₄

CAS 番号

2250025-95-5

Appearance

Solid

Color

Light yellow to brown

SMILES

ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 5.83 mg/mL (15.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6503 mL	13.2517 mL	26.5034 mL
5 mM	0.5301 mL	2.6503 mL	5.3007 mL
10 mM	0.2650 mL	1.3252 mL	2.6503 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

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体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.31%

Select Batch:

データシート (274 KB) SDS (252 KB)

COA (250 KB) HNMR (260 KB) LCMS (98 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91. [Content Brief]

[2]. Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6503 mL	13.2517 mL	26.5034 mL	66.2585 mL
	5 mM	0.5301 mL	2.6503 mL	5.3007 mL	13.2517 mL
	10 mM	0.2650 mL	1.3252 mL	2.6503 mL	6.6259 mL
	15 mM	0.1767 mL	0.8834 mL	1.7669 mL	4.4172 mL