2. Anti-infection
  3. Bacterial
  4. LL-37, human

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.

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カスタムペプチド

CAS 番号 : 154947-66-7

容量 価格（税別） 在庫状況 数量
1 mg $125 在庫あり
5 mg $260 在庫あり
10 mg   お問い合わせ  
50 mg   お問い合わせ  

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カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of LL-37, human:

LL-37, human 関連抗体

Top Publications Citing Use of Products
2D/3D Cell Culture and Differentiation
In Vivo Efficacy Study
RT-PCR
Cell Imaging/Staining
Histological Imaging/Staining
Cell Migration/Invasion Assay
ELISA
Bio/Physico-chemical Assay

    LL-37, human purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Aug 12;10(33):36994-37003.  [Abstract]

    LL-37 (50 μM, 24 h) showed no cytotoxicity to HaCaT and HDF cells.

    LL-37, human purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Aug 12;10(33):36994-37003.  [Abstract]

    LL-37 (50 μM, 24 h) demonstrated effective photodamage repair, increasing the survival of UVB-irradiated HaCaT cells by 14.6% and UVA-irradiated HDF cells by 11.8%.

    LL-37, human purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Aug 12;10(33):36994-37003.  [Abstract]

    LL-37 (50 μM, 24 h) reduced ROS levels in UVB-irradiated HaCaT cells and UVA-irradiated HDF cells.

    LL-37, human purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Aug 12;10(33):36994-37003.  [Abstract]

    LL-37 (50 μM, 12 h) increased the migration rate of HaCaT cells.

    LL-37, human purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Aug 12;10(33):36994-37003.  [Abstract]

    LL-37 (50 μM, 24 h) mitigated MGO-induced AGE formation in HaCaT cells.

    LL-37, human purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Aug 12;10(33):36994-37003.  [Abstract]

    LL-37 (50 μM, 24 h) suppressed α-MSH-induced melanin production in HaCaT cells.

    LL-37, human purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Mar 10:129:111636.  [Abstract]

    LL-37, human TFA (320 μM; 40 μL; every 12 h for 2 d) generated the redness and telangiectasis in the skin of BALB/c mice, with increased range of redness and the redness score.

    LL-37, human purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Mar 10:129:111636.  [Abstract]

    LL-37, human TFA (320 μM; 40 μL; every 12 h for 2 d) elevated the levels of IL-6, TNF-α, IL-1α, and VEGF in BALB/c mice tissues.

    LL-37, human purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Mar 10:129:111636.  [Abstract]

    The present study employed OCT to examine the structural characteristics of the skin of BALB/c mice treated with LL-37, human TFA (320 μM; 40 μL; every 12 h for 2 d).

    LL-37, human purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Mar 10:129:111636.  [Abstract]

    ELISA analysis of IL-17, CCL-3, CXCL-15 level in BALB/c mice treated with LL-37, human TFA (320 μM; 40 μL; every 12 h for 2 d).

    LL-37, human purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Mar 10:129:111636.  [Abstract]

    LL-37, human TFA (320 μM; 40 μL; every 12 h for 2 d) caused a statistically significant increase in the presence of CD4+T cells and MCs within the dermis of BALB/c mice.

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    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing[1][2][3].

    体外実験

    LL-37, human (1-20 μg/mL; 24 h) affects HCECs migration[2].
    LL-37, human (0.0001-5 μg/mL;6-24 h) affects cytokine secretion in HCECs[2].
    LL-37, human (1-100 μg/mL; 24 h) shows dose-dependently cytotoxic to HCECs at concentrations over 10 μg /mL[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    LL-37, human 関連抗体

    Cell Migration Assay [2]

    Cell Line: Human corneal epithelial cell (HCEC)
    Concentration: 1, 2.5, 5, 10 and 20 μg/mL
    Incubation Time: 24 hours
    Result: Dose-dependently stimulated HCEC migration but showed no effect on cell proliferation.

    Cell Viability Assay[2]

    Cell Line: Human corneal epithelial cell (HCEC)
    Concentration: 0.0001, 0.001, 0.01, 0.1, 0.5, 1, and 5 μg/mL
    Incubation Time: 6 and 24 hours
    Result: Dose-dependently increased IL-8, IL-6, IL-1β and TNF-α secretion at 6 and 24 hours in HCEC.
    体内実験

    LL-37, human (0.4-2.0 mg/kg; intratracheal injection once) ameliorates MRSA-induced pneumonia of mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6-8 week-old C57BL/6 mice with MRSA-induced pneumonia[3]
    Dosage: 0.4, 0.8, 1.2, 1.6 and 2.0 mg/kg
    Administration: Intratracheal injection; 0.4-2.0 mg/kg once
    Result: Decreased IL-6 and TNF-α release to attenuated MRSA-induced pneumonia of testing mice.
    分子量

    4493.26

    分子式

    C205H340N60O53
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
    Sequence Shortening

    LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    polypeptide, sealed storage, away from moisture and light, under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (11.13 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.2226 mL 1.1128 mL 2.2256 mL
    5 mM 0.0445 mL 0.2226 mL 0.4451 mL
    10 mM 0.0223 mL 0.1113 mL 0.2226 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    一般には略語で表示されます：C1V1 = C2V2

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.82%

    COA (263 KB) RP-HPLC (262 KB) MS (69 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 0.2226 mL 1.1128 mL 2.2256 mL 5.5639 mL
    5 mM 0.0445 mL 0.2226 mL 0.4451 mL 1.1128 mL
    10 mM 0.0223 mL 0.1113 mL 0.2226 mL 0.5564 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    LL-37, human Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    LL-37, human154947-66-7Bacterial37-residuecathelicidin-derivedpeptidebroad spectrumcorneaHCECintratracheal injectionInhibitorinhibitorinhibit

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    製品名:
    LL-37, human
    製品番号:
    HY-P1222
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