1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Mambalgin 1 TFA

Mambalgin 1 TFA 

Cat. No.: HY-P1441A
Handling Instructions

Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Mambalgin 1 TFA Chemical Structure

Mambalgin 1 TFA Chemical Structure

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Description

Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

Molecular Weight

7397.24

Formula

C₃₁₂H₄₈₂F₃N₈₇O₁₀₂S₈

Sequence

{Leu}{Lys}{Cys}{Tyr}{Gln}{His}{Gly}{Lys}{Val}{Val}{Thr}{Cys}{His}{Arg}{Asp}{Met}{Lys}{Phe}{Cys}{Tyr}{His}{Asn}{Thr}{Gly}{Met}{Pro}{Phe}{Arg}{Asn}{Leu}{Lys}{Leu}{Ile}{Leu}{Gln}{Gly}{Cys}{Ser}{Ser}{Ser}{Cys}{Ser}{Glu}{Thr}{Glu}{Asn}{Asn}{Lys}{Cys}{Cys}{Ser}{Thr}{Asp}{Arg}{Cys}{Asn}{Lys} (Disulfide bridge:Cys3-Cys19;Cys12-Cys37;Cys41-Cys49;Cys50-Cys55)

Sequence Shortening

LKCYQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK (Disulfide bridge:Cys3-Cys19;Cys12-Cys37;Cys41-Cys49;Cys50-Cys55)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Mambalgin 1Mambalgin1Mambalgin-1Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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Mambalgin 1 TFA
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HY-P1441A
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