Isotope-Labeled Compounds

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Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time.

MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds (12439):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-13017S1

Ivacaftor-d19	1413431-22-7	98.10%
Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research.

HY-133111S

3-Hydroxy agomelatine-d3	1079774-23-4	99.69%
3-Hydroxy agomelatine-d₃ is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC₅₀ of 3.2 μM and a K_i of 1.8 μM.

HY-133113S

7-Desmethyl-agomelatine-d3	2749427-92-5	99.69%
7-Desmethyl-agomelatine-d₃ is a deuterium labeled 7-Desmethyl-agomelatine. 7-Desmethyl-agomelatine is a metabolite of Agomelatine.

HY-133152S

Brexpiprazole S-oxide-d8	2748605-29-8	98.72%
Brexpiprazole S-oxide-d₈ (DM-3411 D₈) is a deuterium labeled Brexpiprazole S-oxide (HY-133152). Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.

HY-133167S

Clothianidin-d3	1262776-24-8	99.24%
Clothianidin-d₃ is the deuterium labeled Clothianidin.Clothianidin-d₃ is a neonicotinoid insecticide. Clothianidin-d₃ shows excellent long-term control effect in small doses against various insect pests such as Coleoptera, Thysanoptera, Lepidoptera, Diptera, Homoptera, Heteroptera, Orthoptera and Isoptera families. Clothianidin-d₃ has various application methods and high safety for crops.

HY-133668S

Monoethyl phthalate-d4	1219806-03-7	98.36%
Monoethyl phthalate-d₄ is the deuterium labeled Monoethyl phthalate. Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms.

HY-13636S1

Fulvestrant-d5		99.66%
Fulvestrant-d₅ (ICI 182780-d₅) is a isotope of Fulvestrant (HY-13636). Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC₅₀ of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC₅₀ of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy.

HY-136406S

Bongkrekic acid-13C28		≥98.0%
Bongkrekic acid-¹³C₂₈ is the ¹³C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.

HY-136490S

Psychosine-d5	2260670-12-8	99.0%
Psychosine-d₅ is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.

HY-13690S1

Mitotane-13C6	1261396-21-7	98.62%
Mitotane-¹³C₆ is the ¹³C labeled Mitotane. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions.

HY-139942S

(±)9(10)-EpOME-d4	1215168-54-9	≥99.0%
(±)9(10)-EpOME-d₄ is the deuterium labeled (±)9(10)-EpOME.

HY-141642S

Triheptadecanoin-d5	944795-74-8	99%
Triheptadecanoin-d₅ is the deuterium labeled Triheptadecanoin.

HY-141855S

Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6-d3	259824-51-6	98.42%
Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6-d₃ is the deuterium labeled Acetaldehyde 2,4-Dinitrophenylhydrazone-3,5,6.

HY-141902S

Fmoc-Glu(OtBu)-OH-13C5,15N	1261078-12-9
FMOC-L-Glutamic Acid-¹³C₅,¹⁵N-5-t-butyl ester is the ¹³C and ¹⁵N labeled FMOC-L-Glutamic Acid-5-t-butyl ester.

HY-143789S

Perindopril-d4	1356929-58-2	99.34%
Perindopril-d₄ is the deuterium labeled Perindopril.

HY-143950S

DOTAP-d9 iodide		99.97%
DOTAP-d₉ (iodide) is the deuterium labeled DOTAP iodide.

HY-145397S

(4-NH2)-Exatecan-d5		98.62%
(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan. (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs).

HY-14566S1

Donepezil-d5	1128086-25-8	≥99.0%
Donepezil-d₅ is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.

HY-14648S5

Dexamethasone-d3-1		98.02%
Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-146656S

S-Sulfo-DL-cysteine-d3	2687960-80-9	98.10%
S-Sulfo-DL-cysteine-2,3,3-d₃ is the deuterium labeled S-Sulfo-DL-cysteine-2,3,3.

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