Perindopril-d₄

Cat. No.: HY-143789S: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Perindopril-d₄ is the deuterium labeled Perindopril.

For research use only. We do not sell to patients.

Perindopril-d₄ Chemical Structure

CAS No. : 1356929-58-2

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1 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Perindopril-d₄:

Perindopril In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Perindopril-d₄ is the deuterium labeled Perindopril^[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

372.49

Formula

C₁₉H₂₈D₄N₂O₅

CAS No.

1356929-58-2

Unlabeled CAS

82834-16-0

Appearance

Solid

Color

White to off-white

SMILES

CCOC([C@H](CCC)N[C@](C([2H])([2H])[2H])([2H])C(N1[C@]2([H])[C@](CCCC2)([H])C[C@H]1C(O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (268.46 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6846 mL	13.4232 mL	26.8464 mL
5 mM	0.5369 mL	2.6846 mL	5.3693 mL
10 mM	0.2685 mL	1.3423 mL	2.6846 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (253 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6846 mL	13.4232 mL	26.8464 mL	67.1159 mL
	5 mM	0.5369 mL	2.6846 mL	5.3693 mL	13.4232 mL
	10 mM	0.2685 mL	1.3423 mL	2.6846 mL	6.7116 mL
	15 mM	0.1790 mL	0.8949 mL	1.7898 mL	4.4744 mL
	20 mM	0.1342 mL	0.6712 mL	1.3423 mL	3.3558 mL
	25 mM	0.1074 mL	0.5369 mL	1.0739 mL	2.6846 mL
	30 mM	0.0895 mL	0.4474 mL	0.8949 mL	2.2372 mL
	40 mM	0.0671 mL	0.3356 mL	0.6712 mL	1.6779 mL
	50 mM	0.0537 mL	0.2685 mL	0.5369 mL	1.3423 mL
	60 mM	0.0447 mL	0.2237 mL	0.4474 mL	1.1186 mL
	80 mM	0.0336 mL	0.1678 mL	0.3356 mL	0.8389 mL
	100 mM	0.0268 mL	0.1342 mL	0.2685 mL	0.6712 mL