2. Academic Validation
  3. (±)-odoriferols A-E, five pairs of enantiomeric flavonoids and benzofurans from Dalbergia odorifera with anti-inflammatory activity

(±)-odoriferols A-E, five pairs of enantiomeric flavonoids and benzofurans from Dalbergia odorifera with anti-inflammatory activity

  • Phytochemistry. 2026 Jul:247:114837. doi: 10.1016/j.phytochem.2026.114837.
Weixin Xu 1,  Qing Zhu 2,  Mengfei Wang 2,  Jiarong Li 2,  Xing Dai 2,  Xiaowei Meng 2,  Ni Zhang 1,  Yinju Liu 3,  Lanying Chen 4,  Ronghua Liu 5
Affiliations

Affiliations

  • 1 School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China.
  • 2 School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China; Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM (2024SSY07102), Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China.
  • 3 National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, China.
  • 4 Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM (2024SSY07102), Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China; National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, China. Electronic address: [email protected].
  • 5 School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China; Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM (2024SSY07102), Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China. Electronic address: [email protected].
PMID: 41707931 DOI: 10.1016/j.phytochem.2026.114837
Abstract

Twelve previously unreported compounds, including five pairs of enantiomeric benzofuran and flavonoid derivatives (1-5), along with one benzofuran (6) and one triterpenoid (7), were isolated from the heartwood of Dalbergia odorifera (Fabaceae). Their structures and absolute configurations were elucidated by comprehensive spectroscopic analysis (UV, IR, ESI-MS, NMR) combined with ACD/Structure Elucidator, NMR and ECD calculations. Structurally, compound 1 featured a unique spiro[4,4] skeleton. Compound 2 possessed a rare 6/5/5 tricyclic system containing a 1-methyl-2,7-dioxabicyclo[3.2.1]octan-6-one moiety. Plausible biosynthetic pathways of compounds 1 and 2 were proposed. Seven compounds (1a, 2a, 2b, 4a, 4b, 6 and 7) significantly inhibited NO production in LPS-induced RAW264.7 cells, with IC50 values ranging from 6.3 to 19.9 μM. Notably, compound 7 exhibited the best inhibitory activity with an IC50 value of 6.3 μM.

Keywords

Anti-inflammatory activity; Dalbergia odorifera; Fabaceae; Odoriferols A-G.

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