2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. N-Acetylmannosamine 6-phosphate sodium salt

N-Acetylmannosamine 6-phosphate sodium salt  (Synonyms: ManNAc-6P sodium salt)

製品番号: HY-160821A 純度: 95.0%
COA 取扱説明書 Technical Support

N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy.

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N-Acetylmannosamine 6-phosphate sodium salt

N-Acetylmannosamine 6-phosphate sodium salt 構造式

CAS 番号 : 335275-62-2

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N-Acetylmannosamine 6-phosphate sodium salt 関連抗体

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製品説明

N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy[1][2].

体外実験

N-Acetylmannosamine 6-phosphate (ManNAc-6P) (increasing concentrations; standard EMSA conditions) inhibits the binding of S. aureus NanR-MBP protein to the nanA promoter region in an EMSA-based assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Acetylmannosamine 6-phosphate sodium salt 関連抗体
分子量

323.17

分子式

C8H15NNaO9P
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O[Na])OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C=O)NC(C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 125 mg/mL (386.79 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0943 mL 15.4717 mL 30.9435 mL
5 mM 0.6189 mL 3.0943 mL 6.1887 mL
10 mM 0.3094 mL 1.5472 mL 3.0943 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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純度とドキュメンテーション

純度: 95.0%

COA (249 KB) HNMR (260 KB) CNMR (211 KB) MS (70 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.0943 mL 15.4717 mL 30.9435 mL 77.3587 mL
5 mM 0.6189 mL 3.0943 mL 6.1887 mL 15.4717 mL
10 mM 0.3094 mL 1.5472 mL 3.0943 mL 7.7359 mL
15 mM 0.2063 mL 1.0314 mL 2.0629 mL 5.1572 mL
20 mM 0.1547 mL 0.7736 mL 1.5472 mL 3.8679 mL
25 mM 0.1238 mL 0.6189 mL 1.2377 mL 3.0943 mL
30 mM 0.1031 mL 0.5157 mL 1.0314 mL 2.5786 mL
40 mM 0.0774 mL 0.3868 mL 0.7736 mL 1.9340 mL
50 mM 0.0619 mL 0.3094 mL 0.6189 mL 1.5472 mL
60 mM 0.0516 mL 0.2579 mL 0.5157 mL 1.2893 mL
80 mM 0.0387 mL 0.1934 mL 0.3868 mL 0.9670 mL
100 mM 0.0309 mL 0.1547 mL 0.3094 mL 0.7736 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N-Acetylmannosamine 6-phosphate sodium salt Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetylmannosamine 6-phosphate335275-62-2ManNAc-6PEndogenous MetaboliteGNE myopathyNeu5AcGNE cellsStaphylococcus aureussialic acid biosynthesisnanEsialic acid catabolic pathwaysNanRsialic acid pathwaynanATInhibitorinhibitorinhibit

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製品名:
N-Acetylmannosamine 6-phosphate sodium salt
製品番号:
HY-160821A
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