NNMT-IN-3 

NNMT-IN-3 (Compound 14) is a potent and selective nicotinamide N-methyltransferase (NNMT) inhibitor, with IC₅₀ values of 1.1 nM and 0.4 μM in cell-free and cell-based assays, respectively. NNMT-IN-3 can be used in the research of diseases such as obesity, type 2 diabetes and cancer^[1].

IC₅₀: 1.1 nM (NNMT, cell-free), 0.4 μM (NNMT, cell-based)^[1]

NNMT-IN-3 (22-24 h) potently inhibits recombinant human NNMT in cell-free assays, with an IC₅₀ of 0.0011 μM^[1].
NNMT-IN-3 inhibits NNMT activity in NNMT-overexpressing HEK293 cells, with an IC₅₀ of 0.40 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

592.13

C₃₄H₃₄ClN₇O

3031493-74-7

CC1=CC=C2C(C=C(N2CC3=CC=C(C=C3)Cl)[C@H]4C[C@@H](CN4C(C5=CC6=C(NC(C)=C6)N=C5)=O)N7N=C(C=C7CN)C)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yoshida S, et al. Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides. J Med Chem. 2022;65(15):10655-10673.  [Content Brief]