2. Immunology/Inflammation
  3. NO Synthase
  4. NOS1-IN-1

NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM) , respectively. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP).

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NOS1-IN-1

NOS1-IN-1 Chemische Struktur

CAS. Nr. : 357965-99-2

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NOS1-IN-1 Related Antibodies

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Alle NO Synthase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
nNOS iNOS eNOS

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Beschreibung

NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM) , respectively[1]. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP)[2].

IC50 & Target

nNOS

120 nM (Ki)

Molekulargewicht

589.37

Formel

C14H24F9N7O8
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

N=C(N[N+]([O-])=O)NCCC[C@H](N)CNCCN.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : ≥ 50 mg/mL (84.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6967 mL 8.4836 mL 16.9673 mL
5 mM 0.3393 mL 1.6967 mL 3.3935 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6967 mL 8.4836 mL 16.9673 mL 42.4182 mL
5 mM 0.3393 mL 1.6967 mL 3.3935 mL 8.4836 mL
10 mM 0.1697 mL 0.8484 mL 1.6967 mL 4.2418 mL
15 mM 0.1131 mL 0.5656 mL 1.1312 mL 2.8279 mL
20 mM 0.0848 mL 0.4242 mL 0.8484 mL 2.1209 mL
25 mM 0.0679 mL 0.3393 mL 0.6787 mL 1.6967 mL
30 mM 0.0566 mL 0.2828 mL 0.5656 mL 1.4139 mL
40 mM 0.0424 mL 0.2121 mL 0.4242 mL 1.0605 mL
50 mM 0.0339 mL 0.1697 mL 0.3393 mL 0.8484 mL
60 mM 0.0283 mL 0.1414 mL 0.2828 mL 0.7070 mL
80 mM 0.0212 mL 0.1060 mL 0.2121 mL 0.5302 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NOS1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOS1-IN-1357965-99-2NO SynthaseNitric oxide synthasesNOSNeurological disease,?cerebral palsyCPneuronalInhibitorinhibitorinhibit

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