357965-99-2
Chemical Structure
NOS1-IN-1
- CAS No.: 357965-99-2
- Formula:C14H24F9N7O8
- Molecular Weight:589.37
IUPAC Name: (S)-1-(4-amino-5-((2-aminoethyl)amino)pentyl)-3-nitroguanidine tris(2,2,2-trifluoroacetate)
InChIKey: NYWNMNBIORWOSQ-QTPLPEIMSA-N
SMILES: N=C(N[N+]([O-])=O)NCCC[C@H](N)CNCCN.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Biological Activity: NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM) , respectively[1]. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP)[2].
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NOS1-IN-1 | 95.0% | NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. NOS1-IN-1 exhibits 2617-fold and 325-fold selectivity over eNOS (Ki=39 μM) and iNOS (Ki=325 μM) , respectively. NOS1-IN-1 can be used for the research of neurological disease, including cerebral palsy (CP). | ||||||||||||||||||||
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- [1]. J M Hah, et al. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. J Med Chem. 2001 Aug 2;44(16):2667-70. [Content Brief]
- [2]. Haitao Ji, et al. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann Neurol. 2009 Feb;65(2):209-17. [Content Brief]
Keywords
