2. Cytoskeleton
  3. Integrin
  4. RGD Trifluoroacetate

RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.

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CAS No. : 2378808-45-6

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of RGD Trifluoroacetate:

RGD Trifluoroacetate Related Antibodies

Top Publications Citing Use of Products

    RGD Trifluoroacetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 18;15(1):3343.  [Abstract]

    RGD (0.2 mg/mL) was used to immobilize RAW264.7 cells on the hydrogel and minimize cell leakage during operation.

    RGD Trifluoroacetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 18;15(1):3343.  [Abstract]

    With or without RGD (0.2 mg/mL) modification, the numbers of RAW264.7 cells in the medium before and after loading and the percentage of cells loaded into the iMASSAGE device were shown.

    RGD Trifluoroacetate purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) significantly ameliorated the prostate volume and the prostate weight-to-body weight ratio of testosterone (TP)-induced BPH mice.

    RGD Trifluoroacetate purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) strikingly increased global succinylation levels in testosterone (TP)-induced BPH mice.

    RGD Trifluoroacetate purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2023 Dec 31;253(Pt 1):126499.  [Abstract]

    RGD (1-5 mg; i.v.; 30 d) therapy significantly ameliorated prostate hyperplasia of testosterone (TP)-induced BPH mice, as evidenced by the absence of morphological abnormalities such as excessive proliferation in the glandular epithelium, focal intraluminal papillary folds, and secretion-filled distended ducts.

    View All Integrin Isoform Specific Products:

    View All Isoforms
    αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.

    IC50 & Target

    Integrin[1]
    In Vitro

    RGD Trifluoroacetate is the most effective and most often employed peptide sequence for stimulated cell adhesion on synthetic surfaces. There are 24 integrins binding to ECM molecules in a RGD dependent manner: α3β1, α5β1, α8β1, αIIbβ3, αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, and to some extent α2β1 and α4β1[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    RGD Trifluoroacetate Related Antibodies
    Molecular Weight

    460.36

    Formula

    C14H23F3N6O8
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Arg-Gly-Asp
    Sequence Shortening

    RGD
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 125 mg/mL (271.53 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1722 mL 10.8611 mL 21.7221 mL
    5 mM 0.4344 mL 2.1722 mL 4.3444 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (217.22 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.1722 mL 10.8611 mL 21.7221 mL 54.3053 mL
    5 mM 0.4344 mL 2.1722 mL 4.3444 mL 10.8611 mL
    10 mM 0.2172 mL 1.0861 mL 2.1722 mL 5.4305 mL
    15 mM 0.1448 mL 0.7241 mL 1.4481 mL 3.6204 mL
    20 mM 0.1086 mL 0.5431 mL 1.0861 mL 2.7153 mL
    25 mM 0.0869 mL 0.4344 mL 0.8689 mL 2.1722 mL
    30 mM 0.0724 mL 0.3620 mL 0.7241 mL 1.8102 mL
    40 mM 0.0543 mL 0.2715 mL 0.5431 mL 1.3576 mL
    50 mM 0.0434 mL 0.2172 mL 0.4344 mL 1.0861 mL
    60 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9051 mL
    80 mM 0.0272 mL 0.1358 mL 0.2715 mL 0.6788 mL
    100 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.5431 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    RGD Trifluoroacetate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    RGD2378808-45-6IntegrinInhibitorinhibitorinhibit

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